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- W2373726227 abstract "Objective To analyze the pathological lesion of monkeys caused by neurovirulence test of oral poliovirus vaccine(OPV) and evaluate the two injection methods for the test.Methods Analyze the results of pathological examinations of monkeys used for neurovirulence tests of OPV during 1988-2004.Results The qualification rates of OPV in neurovirulence tests by intracerebral and intraspinal injections during the past 18 years were 99.38% and 98.14% respectively,which showed no significant difference.The 3 batches of vaccines unqualified in the test by intraspinal injection were also unqualified in that by intracerebral injection.By intraspinal injection,more than 90% of the scores for pathological lesion caused by OPV type Ⅲ(Zhong Ⅲ_2 strain) were significantly lower than those by SabinⅢ reference strain,which indicated that,compared with SabinⅢ reference strain,Zhong Ⅲ_2 strain was further attenuated.No significant difference was observed between the scores of neurovirulence tests on a single batch and on the pooling of several batches of OPV.By intracerebral injection,neither pathological lesion rate nor pathological lesion constitution caused by original vaccine showed significant difference from those by 1∶10 diluted vaccine.The pathological lesion rate caused by OPV prepared with Sabin Ⅰ strain(4.88%) was significantly higher than those with SabinⅡ(0.65%) and Zhong Ⅲ_2(0.67%) strains.However,the lesion rates caused by OPV prepared with SabinⅡ and Zhong Ⅲ_2 strains showed no significant difference.The lesion rate in retest(6%) was significantly higher than that in primary test(0.66%).Conclusion Both intracerebral and intraspinal injections were sensitive methods for neurovirulence test of OPV.The results of pathological examinations were accurate and reliable." @default.
- W2373726227 created "2016-06-24" @default.
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- W2373726227 date "2007-01-01" @default.
- W2373726227 modified "2023-09-24" @default.
- W2373726227 title "Analysis of Pathological Lesion Caused by Neurovirulence Test of Oral Poliovirus Vaccine in Monkeys" @default.
- W2373726227 hasPublicationYear "2007" @default.
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