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- W2373743503 abstract "Objective To investigate the relationship between cognitive function and hippocampus metabolic changes measured by H - magnetic resonance spectroscopy(H - MRS) in patients with leukoaraiosis.Methods One hundred and eight patients with hypomnesis were recruited.There was 54 cases in leukoaraiosis(LA) group and also 54 in non-leukoaraiosis(non - LA) group.Mini - Mental State Examination(MMSE),Montreal Cognitive Assessment Scale(MoCA) and Wechsler Memory Scale-Chinese Revised(WMS-CR) were used for assessment.A 3.0T MR was used for STEAM 'H-MRS analysis.The value of N - acetylaspartate(NAA),creatine and phosphocreatine(Cr),myoinositol(mI),choline-containing compounds(Cho) and glutamate complex-α(Glx-α) were measured in the left hippocampus.The ratio including NAA/Cr,ml/Cr,Cho/Cr and Glx-α/Cr were calculated.The differences between two groups were compared.Results Both MMSE and MoCA scores(24.00 and 16.50) in LA group were significantly lower than those in non-LA group(27.00 and 21.00)(P=0.000).In MoCA,the scores of LA group and non-LA group were as follow:1.00 and 3.00 in visuospatial execution,4.00 and 5.00 in attention,1.00 and 2.00 in language,0.00 and 2.00 in delayed recall(P 0.05).In WMS-CR,immediate memory scores(5.06±2.86) and short-term memory scores(32.76±13.31) of LA group were lower than those in the non-LA group which were(7.68±4.41) and(46.95±14.81)(P0.05).No significant difference was shown in NAA/Cr,mI/Cr, Cho/Cr and Glx-α/Cr ratio among two groups.Conclusion Leukoaraiosis may damage cognitive function, mainly in visual execution,attention,language and memory(especially immediate memory and short-term memory).No metabolic change in hippocampus via H-MRS scan was found between LA group and non-LA group.No relation between these changes and left hippocampus metabolic changes was seen." @default.
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- W2373743503 date "2011-01-01" @default.
- W2373743503 modified "2023-09-23" @default.
- W2373743503 title "Study of the relationship between cognitive function and hippocampus metabolic changes in patients with leukoaraiosis" @default.
- W2373743503 hasPublicationYear "2011" @default.
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