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- W2373797455 abstract "Objective:To explore the effects of the combination of Irbesartan and Chinese medicinal formulae jiang tang bao shen fang on the renal oxidative stress and ultramicroscopic structure in early diabetic nephropathy rats.Methods:Diabetic nephropathy rats were induced by streptozocin(STZ),the experimental rats were randomly divided into control,diabetes,diabetes treated with Irbesartan,diabetes treated with traditional Chinese medicine,and diabetes treated with combined Irbesartan and traditional Chinese medicine.Blood glucose(BG),HbAlc,blood cholesterol(TC),trigalloylglycerol(TG),blood ureanitrogen(BUN),serum creatinine(Scr),kidney weight/body weight(S/T),urinary albumin excretion rate(UAER)were measured after 5 weeks.The activities of antioxidant enzymes in renal cortex,including total superoxide dismutase(TSOD),catalase(CAT),and maleicdialdehyde(MDA)were measured by chromatometry,and the podocyte ultrastructure was observed by transmission electronic microscopy.Results:Compared with the group C,the levels of BG、HbAlc、TC、TG、UAER and S/T in group D increased significantly,and creatinine clearance rates(Ccr)decreased obviously.The activities of TSOD and CAT decreased significantly,and the level of MDA increased notably in group D.Meantime,the projections of podocyte were fused,which destroyed the structure of the protective screen in group D.When Irbesartan and Chinese medicinal formulae were used together,all the laboratory indicators improved remarkable than monotherapies.Conclusion:The increasing of oxidative stress and podocyte injury were existed in early diabetic nephropathy rats.The combination therapy of irbesartan and traditional Chinese medicine confers superiority over monotherapies on the changes of oxidative stress and ultramicroscopic structure in early diabetic nephropathy rats.The mechanism may be related to the synergism of the two medicines in the treatment of diabetic nephropathy." @default.
- W2373797455 created "2016-06-24" @default.
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- W2373797455 date "2009-01-01" @default.
- W2373797455 modified "2023-09-23" @default.
- W2373797455 title "Experimental Study of the Combination Therapy of Irbesartan and Chinese Medicinal Formulae on the Renal Oxidative Stress and Ultramicroscopic Structure in Early Diabetic Nephropathy Rats" @default.
- W2373797455 hasPublicationYear "2009" @default.
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