Matches in SemOpenAlex for { <https://semopenalex.org/work/W2373810261> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2373810261 abstract "OBJECTIVE:To study the pharmacokinetics and relative bioavailability of Gliclazide sustained-release tablets,and to validate the bioequivalence between the domestic and the imported Gliclazide sustained-release tablets.METHODS:In Latin square experiment,32 healthy volunteers were given single and multiple oral-dose of Gliclazide sustained-release tablet in foodless condition,and pharmacokinetics and bioequivalence of the two formulations were evaluated and the plasma concentrations were de-termined by HPLC.RESULTS:The main pharmacokinetic parameters of domestic preparation vs.imported preparation after singleoral-dose of Gliclazide sustained-release tablets were as followst:max(6.71±1.43)h vs.(7.38±1.50)h;Cmax(0.813±0.178)μg.mL-1vs.(0.782±0.129)μg.mL-1;AUC0～72(21.29±5.86)μg.h.mL-1 vs.(21.09±5.34)μg.h.mL-1;AUC0～∞(23.19±7.49)μg.h.mL-1vs.(23.15±5.64)μg.h.mL-1;t1/2ke(18.79±5.24)h vs.(20.03±5.67)h.The main steady state pharmacokinetic parameters of do-mestic preparation vs.imported preparation after the multiple-dose of Gliclazide sustained-release tablets were as follows:AUCss(27.85±9.77)μg.h.mL-1 vs.(27.63±10.84)μg.h.mL-1;Cssmax(1.892±0.503)μg.mL-1 vs.(1.829±0.521)μg.mL-1;tssmax(5.33±1.24)h vs.(6.13±1.42)h;Cssmin(0.771±0.379)μg.mL-1 vs.(0.830±0.478)μg.mL-1;DF:(103.8±40.0)% vs.(97.6±52.9)%.CONCLUSION:The two preparations are bioequivalent." @default.
- W2373810261 created "2016-06-24" @default.
- W2373810261 creator A5013914837 @default.
- W2373810261 creator A5042338687 @default.
- W2373810261 date "2010-01-01" @default.
- W2373810261 modified "2023-09-23" @default.
- W2373810261 title "Study on Pharmacokinetics and Bioequivalence of Gliclazide Sustained-release Tablets in Healthy Volunteers" @default.
- W2373810261 hasPublicationYear "2010" @default.
- W2373810261 type Work @default.
- W2373810261 sameAs 2373810261 @default.
- W2373810261 citedByCount "0" @default.
- W2373810261 crossrefType "journal-article" @default.
- W2373810261 hasAuthorship W2373810261A5013914837 @default.
- W2373810261 hasAuthorship W2373810261A5042338687 @default.
- W2373810261 hasConcept C112705442 @default.
- W2373810261 hasConcept C134018914 @default.
- W2373810261 hasConcept C181389837 @default.
- W2373810261 hasConcept C185592680 @default.
- W2373810261 hasConcept C22979827 @default.
- W2373810261 hasConcept C2777448766 @default.
- W2373810261 hasConcept C42404028 @default.
- W2373810261 hasConcept C43617362 @default.
- W2373810261 hasConcept C555293320 @default.
- W2373810261 hasConcept C71924100 @default.
- W2373810261 hasConcept C98274493 @default.
- W2373810261 hasConceptScore W2373810261C112705442 @default.
- W2373810261 hasConceptScore W2373810261C134018914 @default.
- W2373810261 hasConceptScore W2373810261C181389837 @default.
- W2373810261 hasConceptScore W2373810261C185592680 @default.
- W2373810261 hasConceptScore W2373810261C22979827 @default.
- W2373810261 hasConceptScore W2373810261C2777448766 @default.
- W2373810261 hasConceptScore W2373810261C42404028 @default.
- W2373810261 hasConceptScore W2373810261C43617362 @default.
- W2373810261 hasConceptScore W2373810261C555293320 @default.
- W2373810261 hasConceptScore W2373810261C71924100 @default.
- W2373810261 hasConceptScore W2373810261C98274493 @default.
- W2373810261 hasOpenAccess W2373810261 @default.
- W2373810261 hasRelatedWork W2350333278 @default.
- W2373810261 hasRelatedWork W2351790274 @default.
- W2373810261 hasRelatedWork W2352515170 @default.
- W2373810261 hasRelatedWork W2355414047 @default.
- W2373810261 hasRelatedWork W2357354247 @default.
- W2373810261 hasRelatedWork W2358841812 @default.
- W2373810261 hasRelatedWork W2358999229 @default.
- W2373810261 hasRelatedWork W2361391958 @default.
- W2373810261 hasRelatedWork W2363213175 @default.
- W2373810261 hasRelatedWork W2375389209 @default.
- W2373810261 hasRelatedWork W2376697888 @default.
- W2373810261 hasRelatedWork W2376750432 @default.
- W2373810261 hasRelatedWork W2378909922 @default.
- W2373810261 hasRelatedWork W2379755873 @default.
- W2373810261 hasRelatedWork W2379788714 @default.
- W2373810261 hasRelatedWork W2383654499 @default.
- W2373810261 hasRelatedWork W2387060759 @default.
- W2373810261 hasRelatedWork W2387179868 @default.
- W2373810261 hasRelatedWork W2389532644 @default.
- W2373810261 hasRelatedWork W2979065300 @default.
- W2373810261 isParatext "false" @default.
- W2373810261 isRetracted "false" @default.
- W2373810261 magId "2373810261" @default.
- W2373810261 workType "article" @default.