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- W2373817907 abstract "Objective To establish a manipulation-easy animal model of post-ischemic myocardial fibrosis and in-vestigate the mechanism of collagen deposition.Methods Twenty BALB /c mice were randomly divided into two groups: the experimental group and control group.The mice in the experimental group were subjected to hypodermic injection with isoproterenol in a dose of 50 mg /kg.The injection was carried out twice a day for consecutive 10 days.Physiological saline was injected with the same method in the control group.The surface electrocardiogram was measured.Forty-five days after injection,collagen distribution was observed using sirius red staining.Expression levels of matrix metalloproteinase-9(MMP-9) And tissue inhibitor of metalloproteinase-1(TIMP-1) in myocardium were detected by fluorescent qRT-PCR.The expression of laminin(LN)in the heart,liver and kidney was detected by immunohistochemistry.Results The experi-mental group had increased ventricular arrhythmia and faster heart rate,and had increased levels of MMP-9,TIMP-1,LN and collagen deposition in the myocardium than those in the control group(P 0.05).The expression of LN in the liver and kidney showed no significant difference(P 0.05).Conclusions Isoproterenol-induced collagen deposition in the experiment is a reproducible,handy and credible method to establish an animal model of myocardial fibrosis.MMP-TIMP imbalance is involved in the mechanism." @default.
- W2373817907 created "2016-06-24" @default.
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- W2373817907 date "2011-01-01" @default.
- W2373817907 modified "2023-09-28" @default.
- W2373817907 title "Establishment of a mouse model of myocardial fibrosis with isoproterenol and the mechanism of collagen deposition" @default.
- W2373817907 hasPublicationYear "2011" @default.
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