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- W2373822759 abstract "Objective To observe the expression and distribution of Slit2 in rats after acute spinal cord injury (SCI) and the mechanism of of the growth cone guidance.Methods SCI model of adult SD rats was established by using Allen's method.The samples were taken on the post-injury day 2,4,7 and 14.By using semiquantative RR-PCR,the expression of Slit2 mRNA was detected.Immunocytochemistry was done to detect the distribution of Slit-2 protein expression.Results RT-PCR revealed that the ex- pression of Slit-2 mRNA in the injured spinal cord was up-regulated,reached the peak at 7th day,then gradually decreased.Immunocytochemistry indicated the positive signal of Slit 2 appeared at the extensive area of spinal cord gray,located in the astrocytes.Conclusion In rats after SCI,Slit 2 mRNA was up- regulated and extensively distributed in the injured spinal gray matter.Slit 2 is likely to do something im- portantly with axon regeneration after SCI." @default.
- W2373822759 created "2016-06-24" @default.
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- W2373822759 date "2006-01-01" @default.
- W2373822759 modified "2023-09-26" @default.
- W2373822759 title "Expression of Slit2 in rats after aute spinal cord injury" @default.
- W2373822759 hasPublicationYear "2006" @default.
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