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- W2373832422 abstract "This study was carried out to investigate the mechanism of analgesic and anesthetic activity of xylazine. Radioimmunoassay was used to measure the change of beta-endorphin(β-Ep) in the blood, hypothalamus and pituitary gland when xylazine was given. The rats were assigned to 3 groups and treated as follows: saline control, analgesic groups(25 mg/kg), anesthetic groups(55 mg/kg). The blood β-Ep level of analgesic groups and anesthetic groups increased significantly at 5 min (P0.01) , reached the top level at 30 min (P0.01), and then decreased gradually until 90 min (analgesic groups, P0.01) or 120 min (anesthetic groups, P0.01). But the highest level in hypothalamus and pituitary gland occured 15 min prior to the top level in blood. In the different dose-treated groups, the level of β-Ep in blood, hypothalamus and pituitary gland increased with the dose given correlatively (P0.01). It is inferred that xylazine may enhance the synthesis and excretion of beta-endorphin in hypothalamus and pituitary gland." @default.
- W2373832422 created "2016-06-24" @default.
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- W2373832422 date "2002-01-01" @default.
- W2373832422 modified "2023-09-27" @default.
- W2373832422 title "Effect of Xylazine on the Content of β-endorphin in the blood, hypothalamus and pituitary gland in Rats" @default.
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