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- W2373839038 abstract "Objective To observe the effects of intensive insulin treatment on oxidative stress and islet β cell apoptosis in type 2 diabetic rats.Methods 36 Wistar rats were randomly divided into two groups:normal control group and high fat diet group.Rats in normal control group were feed by purified water and basical feedstuff.Rats in high fat diet group were feed by high fat and basical feedstuff.After 10 days,rats in high fat group were injected with streptozotocin.After 3 days,rats in high fat group were randomly divided into two groups:diabetes control group and insulin treatment group.The course of treatment is 4 weeks.After 10 days by fat milk intragastric administration,after 3 days of streptozotocin injection and after 4 weeks treatment,we measure each index.After experiment,we measure SOD,MDA,and GSM in blood serum and hepatic tissue of rats.we measure islet β cell apoptosis by terminal-deoxynucleoitidyl transferase mediated nick end la.Results After 4 weeks intensive insulin treatment,compare with the diabetes control group,The blood serum and hepatic tissue SOD、GSM in insulin treatment group are increased and MDA is decreased.Isletβcell apoptosis rates is decreased(P0.05).Conclusion The method of insulin intensive treatment can decrease oxidative stress and isletβcell apoptosis." @default.
- W2373839038 created "2016-06-24" @default.
- W2373839038 creator A5052133482 @default.
- W2373839038 date "2011-01-01" @default.
- W2373839038 modified "2023-09-23" @default.
- W2373839038 title "The Effects of Intensive Insulin Treatment on Oxidative Stress and IsletβCell Apoptosis in Type 2 Diabetic Rats" @default.
- W2373839038 hasPublicationYear "2011" @default.
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