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- W2373840390 abstract "Objective:To investigate the relevance of HLA-DQA1-DQB1 linked gene haploid with the slow progress adult type 1 diabetes mellitus(SPIDDM) and fast progressive type 1 diabetes mellitus(FPIDDM).Methods:HLA-DR-DQ gene haplotypes in 102 SPIDDM patients and 130 FPIDDM patients were determined by PCR/SSP techniques.Results:①The frequencies of HLA-DQA1*0301-DQB1*0201 and DQA1*0501-DQB1*0201 gene haplotypes were significantly higher in both SPIDDM(Pc0.001) and FPIDDM(Pc0.001) patients.②The frequencies of HLA-DQA1*0301-DQB1*0301 and DQA1*0301-DQB1*0602 gene haplotypes were significantly higher in SPIDDM patients(Pc0.001).③The frequencies of HLA-DQA1*0301-DQB1*0302,DQA1*0301-DQB1*0303 and DRB1*0301-DQA1*0301-DQB1*0201 gene haplotypes were significantly higher in FPIDDM patients(all Pc0.05).DQA1*0102 allele 16 cases in SPIDDM group,accounting for 15.69%,10 cases in FPIDDM group,accounting for 7.69%(P0.05);DQA1*03 gene SPIDDM group of 47 patients(46.08%),FPIDDM group of 79 patients(60.77%)(P0.05);DQB1*0601 gene SPIDDM group of 10 cases(9.8%),FPIDDM group of 4 cases(3.08%)(P0.01).Conclusion:Though SPIDDM and FPIDDM are both autoimmune diabetes,but its HLA phenotype is not the same,and different HLA phenotype may be one of the factors which determine the mode of onset and progression of different ways." @default.
- W2373840390 created "2016-06-24" @default.
- W2373840390 creator A5059549942 @default.
- W2373840390 date "2011-01-01" @default.
- W2373840390 modified "2023-09-23" @default.
- W2373840390 title "Features research of HLA-DQA1-DQB1 linked genes in type 1 diabetes mellitus" @default.
- W2373840390 hasPublicationYear "2011" @default.
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