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- W2373848938 abstract "OBJECTIVE To study the mechanism and effect of Chinese medicine Yibiqing on rat’s acute hemorrhagic necrotizing pancreatitis-acute lung injury (AHNP-ALI).METHODS 96 SD rats were divided into 4 groups randomly:sham operated controls(n=24);AHNP model(n=24);AHNP+Yibiqing decoction(n=24) group and sandostatin group (n=24),AHNP model was induced by intra-ductal administration of 5% sodium taurocholate.Reverse transcriptase-polymerase chain was applied to detect the expression of TLR4mRNA and caspase-1mRNA in pulmonary alveolar macrophages of broncho-alveolar lavage on various hours (3,6,12,24 h) after the model established.The degree of injury in the lung was judged by the pathologic score of the lung.RESULTS The gradually fall of TLR4mRNA、caspasel mRNA expression of BALF-PAMs in YBQ group、SS group,compared to the AHNP group,have a significant statistical difference(P0.05).CONCLUSION YBQ could reduce significantly the expression of TLR4mRNA and the caspase-1mRNA of pulmonary alveolar macrophages and amend the AHNP-ALI of rats." @default.
- W2373848938 created "2016-06-24" @default.
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- W2373848938 date "2010-01-01" @default.
- W2373848938 modified "2023-09-25" @default.
- W2373848938 title "Effect of Chinese medicine Yibiqing on rat’s acute lung injury induced by acute hemorrhagic necrotizing pancreatitis" @default.
- W2373848938 hasPublicationYear "2010" @default.
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