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• W2373856474 abstract "Objective To evaluate the clinical curative effect and safety of different doses of calf pulmonary surfactant in the treatment of premature infants with respiratory distress syndrome.Methods The premature infants with respiratory distress syndrome were treated with three different doses of calf pulmonary surfactant.93 cases met the inclusive criteria among the whole cases.There were 31 cases treated with small doses of calf pulmonary surfactant( 40-70 mg / kg),31 cases treated with middle doses of calf pulmonary surfactant( 70-100 mg / kg) and 31 cases treated with large doses of calf pulmonary surfactant( 100-140 mg / kg).The results of blood gas analysis were compared among the three groups before and after treatment,including p H,arterial oxygen tension and arterial carbon oxygen tension.Other items of comparison included sex,gestational age,birth weight,cesarean section,Apgar scores,amniotic fluid,need for repeated drug use,need for mechanical ventilation,duration of mechanical ventilation,duration of oxygen therapy,duration of hospital stay,outcomes,complications and average hospital expenses.Results There was no significant difference in sex,gestational age,birth weight,cesarean section,Apgar scores,amniotic fluid and premature rupture of membranes among the three groups( P 0.05).6 hours after the first application of pulmonary surfactant,the p H value and the arterial oxygen tension of the whole infants increased in varying degrees,and the arterial carbon oxygen tension of the whole infants decreased in varying degrees( P 0.05).The differences of p H value,arterial oxygen tension and arterial carbon oxygen tension among the three groups had no statistical significance before the treatment( P 0.05).The difference of the curative effect among the three groups( including the need for repeated drug use,the need for mechanical ventilation,the duration of mechanical ventilation and the duration of oxygen therapy) had no statistical significance( P 0.05).There was no significant difference in complication morbidity and the cure rate among the three groups( P 0.05),but it showed significant differences in the average hospital expenses and the average duration of hospital stay among the three groups( P 0.05).Compared with the large dose group,the average hospital expenses in the middle dose group decreased.And compared with the small dose group,the average duration of hospital stay in the middle dose group decreased.Conclusion The clinical curative effect and safety of the three doses of calf pulmonary surfactant are analogous in the treatment of premature infants with respiratory distress syndrome.But the average hospitalization expenses in the middle doses group is less than that of the large doses groups,and the average duration of hospitalization in the middle dose group is less than that of the small doses group." @default.
• W2373856474 created "2016-06-24" @default.
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• W2373856474 date "2015-01-01" @default.
• W2373856474 modified "2023-09-28" @default.
• W2373856474 title "Observation on the clinical curative effect of different doses of calf pulmonary surfactant in the treatment of premature infants with respiratory distress syndrome" @default.
• W2373856474 hasPublicationYear "2015" @default.
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