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- W2373868432 abstract "OBJECTIVE To investigate the pharmacodynamic and p harmacokinetic properties of vancomycin during continuous veno-venous hemofiltr ation (CVVH) therapy in a patient with renal failure.METHODS A patient with kidney failure received 0.5g vancomycin infusion during CVVH th erapy.On 3~rd day and 16th day during the therapy,blood samples were collec ted after the dosing.The serum concentrations of vancomycin were measured by TDx .The pharmacokinetic parameters were calculated using PKBP-N1 software.The phar macodynamic targets of vancomycin were observed.RESULTS The pharmacokinetics of vancomycin during CVVH was fitted well with open two-compar tment model.On the 3~rd day of CVVH therapy, the pharmacokinetic parameters were:t 1/2α0.41 h,t 1/2β5.75 h,V c 21.92 L,c ma x 22.81 μg·mL~-1,c min 5.82 μg·mL~-1,CL 3.49 L and V ss 28.32 L,respectively.On the 16th day, the PK parameters were:t 1/2α 0.61 h,t 1/2β 33.23 h,V c 12.92 L,c max 38.7 0 μg·mL~-1,c min 16.50 μg·mL~-1,CL 0.367 L and V ss 17.69 L,respectively.The pharmacodynamic targets of vancomycin were bod y temperature,white blood count and bacteria in phlegm.CONCLUSION It demonstrated that the pharmacokinetic properties of vancomycin changed with time during CVVH treatment.Therefore,the monitoring of blood drug concentra tion during the therapy was necessary and the dosage regiment should be adjusted accordingly." @default.
- W2373868432 created "2016-06-24" @default.
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- W2373868432 date "2001-01-01" @default.
- W2373868432 modified "2023-09-23" @default.
- W2373868432 title "Investigation of the pharmacodynamics and pharmacokinetics of vancomycin during continuous veno-venous hemofiltration therapy in a patient with renal failure" @default.
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