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- W2373869854 abstract "Objective:To investigation the expressions of α-actinin-4 and Desmin in adriamycin-induced nephropathy(AN) rats and to further explore the effects of Qufeng Tongluo Recipe on the expressions of α-actinin-4 and Desmin in filtration barrier of kidney glomerulus,expecting to provide evidence for its clinical application.And to discuss the pathogenesis theory about pathogenic wind hiding in kidney collaterals in chronic kidney disease(CKD).Methods:86 rats with adriamycin nephrophthy were randomly divided into the normal control group(A,n=24),the nephropathy model group(B),the Qufeng group(C),Qufeng and prednisone group(D),prednisone group(E).With treatment being given respectively,the renal tissue samples were taken out in each group.The distribution and quantity expressions of α-actinin-4 and Desmin were examined by immunohistochemisty.And the ultrastructure and expressions of α-actinin-4 and Desmin were examined by electron microscope observation.Results: After adriamycin injection,the expressions of α-actinin-4 and Desmin in the podocyte were up-regulated(P0.01).The quantity of α-actinin-4 did not change(P0.05) while Desmin increased(P0.01).At the end of interference,the ultrastructure in C,D and E groups came to improve and the average optical expressions of α-actinin-4 and Desmin were decreased,especially that in D group(P0.01)and significant deviation was not observed between C and E groups(P0.05).Distributions of α-actinin-4 and Desmin in C,D and E groups came regular(P0.05).Conclusion:The abnormal expression and distribution of α-actinin-4 and Desmin are the molecular mechanism that leads to the occurrence and development of proteinuria in AN rats.The improvement of the expression and distribution of α-actinin-4 and Desmin in GBM in glomerulus is likely caused by the effects of Qufeng Tongluo Recipe on nephritic syndrome.It is proved that hepathogenesis theory about pathogenic wind hiding in kidney collaterals is accordance with the clinical reality and composing prescriptions and treatment of Qufeng Tongluo is reliable in CKD." @default.
- W2373869854 created "2016-06-24" @default.
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- W2373869854 date "2013-01-01" @default.
- W2373869854 modified "2023-09-23" @default.
- W2373869854 title "Effect and Mechanism of Qufeng Tongluo Recipe on Expressions of α-actinin-4 and Desmin in Adriamycin-induced Nephropathy Rats" @default.
- W2373869854 hasPublicationYear "2013" @default.
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