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- W2373886218 abstract "OBJECTIVE The present study has evaluated the toxicity of different compatibility ratio of Sargassum pallidum(Turn.)C.Ag.and Glycyrrhiza uralensis Fisch.By determining mortality after single oral administration in ICR mice.METHODS The median lethal death(LD50) and its 95% confidence limit were calculated by the morality of mice in acute toxicity testing.Five different compatibility ratios 1∶3,1∶2,1∶1,1∶0.33,1∶0.17 of Sargassum and Glycyrrhiza were designed in accordance with the dosage range of Sargassum and Glycyrrhiza in the Pharmacopeia,in which the dose of Sargassum was fixed on the basis of the LD50.Otherwise,the high dose 90 g/kg of Glycyrrhiza and the dose 30 g/kg of Sargassum are setted as two control groups.General behavior,adverse effects and mortality were recorded for up to 14 days post treatment.RESULTS When the ratio of Sargassum and Glycyrrhiza is 1∶3 and 1∶1,the mice morality is 100%;the ratio of two herbs is 1∶2,the mice morality is 80%;the Sargassum control group and the ratio of two herbs is 1∶0.33,the morality is 60%;the ratio is 1∶0.17,the morality is 50%;the morality of Glycyrrhiza control group is 0%.CONCLUSION The results show that toxic effects are increased when the dose of Glycyrrhiza is higher than the dose of Sargassum." @default.
- W2373886218 created "2016-06-24" @default.
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- W2373886218 date "2012-01-01" @default.
- W2373886218 modified "2023-10-07" @default.
- W2373886218 title "Acute Toxicity Studies of Different Compatibility Ratio of Sargassum and Glycyrrhiza in Mice" @default.
- W2373886218 hasPublicationYear "2012" @default.
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