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- W2373887889 abstract "Nine novel 1,2,4-triazine derivatives bearing benzimidazole moiety have been synthesized by condensation of 2-aryloxymethylbenzimidazole-1-acetylhydrazines with various substituted phenacyl bromides.The structures were confirmed by IR,1HNMR spectra and elemental analysis.These compounds were screened based on anticancer and anti-diabetic activities.The results indicated that most compounds exhibited high activities against Cdc25B phosphatase with the inhibitory rate in the range of 58%~93%,and compounds 3-[(2-phenoxymethyl)benzimidazole-1-methylene]-6-(4-methoxylphenyl)-1,2,4-triazine and 3-[(2-phenoxymethyl)benzimidazole-1-methylene]-6-biphenyl-1,2,4-triazine showed high activities against PTP1B with the inhibitory rate 59.99% and 87.47%,respectively.The target compounds could be used as potential anti-cancer and anti-diabetes reagents." @default.
- W2373887889 created "2016-06-24" @default.
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- W2373887889 date "2012-01-01" @default.
- W2373887889 modified "2023-09-30" @default.
- W2373887889 title "Synthesis,characterization and bioactivities of novel 1,2,4-triazine derivatives" @default.
- W2373887889 hasPublicationYear "2012" @default.
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