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- W2373888983 abstract "Objective To study the role of β-catenin protein in the carcinogenesis of nasopharyngeal carcinoma(NPC).Methods Immunohistochemical method combined with tissue microarrays were used for detecting the expression and localization of β-catenin protein in nasopharyngeal tissue with different pathological morphology.Results Low positive percentage of of β-catenin protein expression in cell membrane of NPC(19.0%) and high expression of β-catenin protein in the cytoplasm/ nucleus of NPC(71.3%) were detected.The aberrant positive percentage of cytoplasm/ nucleus of β-catenin expression in the NPC was significantly higher than those in atypically hyperplastic nasopharyngeal epithelium(P0.01),simply hyperplastic nasopharyngeal epithelium(P0.01) and normal nasopharyngeal epitheliun(P0.01),respetively.Expression of β-catenin protein in the cytoplasm/nucleus of keratinizing nasopharyngeal squamous cell carcinoma was significantly lower than that in the undifferentiated nasopharyngeal carcinoma and no keratinizing nasopharyngeal squamous cell carcinoma(P0.01).The aberrant expression of cytoplasm/ nucleus of β-catenin protein in clinical Ⅲ and Ⅳ-staged NPC and NPC with lymph node metastasis was evidently higher than that in Ⅰ and Ⅱ-staged NPC(P0.01) and that without lymph node metastasis(P0.01).Conclusion The aberrant expression of β-catenin protein in the cytoplasm/nucleus of NPC maybe play an important role in the carcinogenesis,invasion,metastasis and development of nasopharyngeal carcinoma.The cytoplasm/nucleus positive expression of β-catenin might be used as a molecular marker to predict clinical progress and invasive metastasis of NPC." @default.
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- W2373888983 date "2012-01-01" @default.
- W2373888983 modified "2023-09-28" @default.
- W2373888983 title "Role of aberrant expression of β-catenin protein in carcinogenesis of nasopharyngeal carcinoma" @default.
- W2373888983 hasPublicationYear "2012" @default.
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