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- W2373890738 abstract "Objective: The purpose of this study was to optimize carbon tetrachloride-induced hepatotoxicity in the rat with respect to dose and time course. Method: Carbon tetrachloride with different dosage was given to SD rats by abdominal injection. Rat ALT and AST in serum were analyzed 48 h and rats liver were observed with routine pathology technique, to determine mice livers′ functional and morphological changes after administration. Results: The serum level of ALT and AST increased significantly in 3A~7A CCl4 groups compared with the control group (P0.05 or P0.01). The pathological changes in can be seen in every ccl4 group, the damnification degree of liver cells were remarkably aggravated with the control group. Deceased rats were seen in 6A and 7A group. Conclusion: Ameliorated acute liver injury model of mice was established, which has definite liver injury with lower mortality rate and less damnification to other organs, can be used for the mechanism and treatment research of acute liver injury." @default.
- W2373890738 created "2016-06-24" @default.
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- W2373890738 date "2004-01-01" @default.
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- W2373890738 title "Amelioration of SD rats acute liver injury model induced by carbon tetrachloride" @default.
- W2373890738 hasPublicationYear "2004" @default.
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