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• W2373890992 abstract "Objective:To explore the effect of DHA intervention of pregnant rats with intrauterine infection on inflammation state of cerebral tissues of neonatal rats exposure to perinatal inflammation. Methods:All the neonatal rates were divided into three groups randomly.The neonatal rats in control group were treated with pouring physiological saline solution into stomach until delivery from the first day of pregnancy,then on the 17th day and 18th day during pregnancy,the rats were treated with intraperitoneal injection of physiological saline solution(0.6 ml).The rats in LPS group(model group) were treated with pouring physiological saline solution into stomach,then on the 17th day and 18th day during pregnancy,the rats were treated with intraperitoneal injection of LPS,the amount was 350μg/kg.The rats in LPS+DHA group(intervention group) were treated with pouring DHA(130 mg/kg) into stomach until delivery from the first day of pregnancy,then on the 17th day and 18th day during pregnancy,the rats were treated with intraperitoneal injection of LPS,the amount was 350μg/kg.The brain tissue specimens of rats on the 21nd day of pregnancy,the first day,seventh day and fourteenth day after birth were obtained in the three groups,HE staining method was used to observe the pathological changes of brain tissues at different time points,immunohistochemical method was used to detect the expression level of microglial cells with positive OX42 in brain tissues.The transcriptional level of TNF-α mRNA in brain tissues was detected by Q-RT-PCR. Results:In model group,edema and cells with immature morphology were found at early period in white matter,even combined with focal hemorrhage,at late period,the trend of nerval fiber in white matter was in disorder,the tissues were loose,the number of cells decreased.In intervention group,many oedematous cells were found at early period in white matter,no apparent hemorrhagic focus and reticular softening lesion were found,on the fourteenth day of pregnancy,the morphology was similar to that in control group.Compared with control group,the positive expression rate of OX42 in microglial cells on the fourteenth day of pregnancy in model group was higher(P0.05);in intervention group,the positive expression rate of OX42 on the seventh day of pregnancy was higher(P0.05),but there was no significant difference on the fourteenth day of pregnancy(P0.05).The positive expression rates of OX42 at different time points in intervention group were significantly lower than those in model group(P0.05).In model group,the expression level of TNF-α mRNA on the seventh day of pregnancy was higher(P0.05),but there was no significant difference on the fourteenth day of pregnancy(P0.05);the expression level of TNF-α mRNA in intervention group was significantly lower than that in model group until the seventh day of pregnancy(P0.05),but there was no significant difference on the fourteenth day of pregnancy(P0.05). Conclusion:Intrauterine LPS infection can induce inflammation reaction of fetal brain tissues,supplementation of DHA during pregnancy can promote the recovery of brain injury by reducing the continuous activation of microglial cells and the expression of inflammatory cytokines and then inhibit inflammatory reaction of fetal brain tissues." @default.
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• W2373890992 date "2011-01-01" @default.
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• W2373890992 title "Effect of DHA intervention of pregnant rats with intrauterine infection on inflammation state of cerebral tissues of neonatal rats" @default.
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