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- W2373896706 abstract "AIM:To observe the effect of oxymatrine on the expression of Toll-like receptor 4 (TLR4) in brain tissue surrounding cerebral ischemic rats. METHODS: The FCI model with thread embolism of middle cerebral artery occlusion (MCAO) in rats was made, 80 male SD rats were divided randomly into shamed-operation, saline and oxymatrine groups, and the oxymatrine group was further divided into two sub-groups which were dealt with the low and high dose of oxymatrine. The expression level of TLR4 and TLR4 mRNA in the brain tissue surrounding cerebral ischemic was determined simultaneously by the usage of immunohistochemical and RT-PCR method respectively. RESULTS: The expression of TLR4 gene in saline group was higher evidently than that in shamed-operation group (P0.01), and was obviously lower in oxymatrine group with higher dose than that in saline group(P0.01). TLR4 protein similer to gene. CONCLUSION: Up-regulation of TLR4 expression can be found in saline group. Oxymatrine can inhibit the expression of TLR4.The inhibitory effects of oxymatrine on cerebral ischemic may be associated with the inhibition of TLR4 expression." @default.
- W2373896706 created "2016-06-24" @default.
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- W2373896706 date "2009-01-01" @default.
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- W2373896706 title "Effect of oxymatrine on the expression of TLR4 in brain tissue on focal cerebral ischemic rats" @default.
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