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- W2373918544 abstract "Background and purpose:Liver metastasis of pancreatic cancer occurs at the later stage of the disease, and also is the main cause of death. Since the tumor metastasis is quite a complex process, the establishment of a liver metastatic model is the key step for the study of the mechanism of pancreatic cancer liver metastasis. Screening human pancreatic carcinoma cell lines with highly metastatic potential in the liver of nude mice is by the method of intrasplenic inoculation of tumor cells which were continuously injected into the spleen, and then its metastatic property was analyzed. Methods:Pancreatic carcinoma SW1990 cells from liver metastatic foli of the mice were cultured in vitro and subsequently injected into the spleens of nude mice. By repeating the procedures four times, we were able to obtain a cell line SW1990H4; the comparison of SW1990H4 cells with SW1990 cells was done in terms of karyotype,cell proliferation,cell cycle distribution,invasion of cells、tumorigenicity ,liver metastastatic potential and metastatic related gene expression including MMP-2,MMP-9,VEGF,bFGF, E-cadherin mRNA level.Results:The karyotype and cell cycle distribution had no significant difference between SW1990H4 cells and parental SW1990 cells(P0.05)。There were significant differences between SW1990H4 cells and parental SW1990 cells(P0.05) in terms of cell proliferation,invasion of cells, and liver metastastatic potential。Metastatic related genes expression like MMP-2,VEGF, bFGF, E-cadherin were higher at mRNA level in SW1990H4 cells than those in parental SW1990 cells, but not MMP-9.Conclusions:SW1990H4 cells are human pancreatic carcinoma lines with highly metastatic potential in the liver of nude mice, the cells is well characterized and could be useful for the study of mechanism of pancreatic carcinoma liver metastasis and the screening of medicine for liver metastasis." @default.
- W2373918544 created "2016-06-24" @default.
- W2373918544 creator A5061000490 @default.
- W2373918544 date "2007-01-01" @default.
- W2373918544 modified "2023-09-23" @default.
- W2373918544 title "Establishment human pancreatic carcinoma cell lines with highly metastatic potential in the liver of nude mice and its significance" @default.
- W2373918544 hasPublicationYear "2007" @default.
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