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- W2373924352 abstract "Objective: To study the function of interferon-inducible protein-10(IP-10) in ACD through observing its effect on Thl/Th2 cytokines.Methods: The ACD mouse model was established with 2,4-dinitrochlorobenzene(DNCB).After the separation and purification of spleen lymphocytes from mice,spleen lymphocyte was co-cultured with IP-10.RT-RCR was used to detect the mRNA of IFN-γ and IL-4.2-△△CT method was used to analyze the difference of IFN-γ and IL-4 mRNA among the four groups.Results: Compared with the control group,20 and 100 ng/ml concentration groups of IP-10 could remarkably promote the expression of IFN-γ in vitro culture CD4+T cell of ACD mouse(P 0.01,P 0.05),while there was no significant difference between the 10 ng/ml concentration group of IP-10 and control group.There was significant difference among three different concentration groups of IP-10 in their promoting the expression of IFN-γ in vitro culture CD4+ T cell(P 0.01,P 0.05);There was no significant difference among the three different concentration groups of IP-10 on the expression of IL-4 in vitro culture CD4+T cell,as well as when they compared with the control group(P﹥0.05).Conclusion: IP-10 may play an important role in the imbalance between Th1 and Th2 by inducing the expression of IFN-γ,which promotes the development of ACD." @default.
- W2373924352 created "2016-06-24" @default.
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- W2373924352 date "2008-01-01" @default.
- W2373924352 modified "2023-10-03" @default.
- W2373924352 title "Effect of IP-10 on Th1/Th2 cytokines in the model of allergic contact dermatitis" @default.
- W2373924352 hasPublicationYear "2008" @default.
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