Matches in SemOpenAlex for { <https://semopenalex.org/work/W2373956858> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2373956858 abstract "Objective To investigate the effect of all-trans-retinoid(ATRA) on the migration of endothelial cells and the expression of gelatinases. Methods In vitro migration assay was used to determine the effect of ATRA on the endothelial cell migration induced by phorbol 12-myristate-13-acetate (PMA), semi-quantitative RT-PCR and Western blot were used to observe the effect of ATRA on the gelatinase expression at mRNA and protein levels respectively, while the proteolytic activities of gelatinases were assessed by zymography. Results The endothelial cell migration elicited by PMA was significantly inhibited when incubated with 0.1 μmol/L, 1.0 μmol/L and 10.0 μmol/L ATRA. Compared with the control, the inhibition rates were (44.68 ± 7.79)%, (65.20 ± 4.59)% and (78.37 ± 2.58)%, respectively. ATRA also reduced the expression and activities of gelationases in a dose dependant manner. At 10 μmol/L concentration, the inhibition rate of mRNA expression, protein expression and protein activities for gelatinase A was (59.39 ± 7.98)%, (78.40 ± 3.23)% and (53.02 ± 7.23)%, respectively. For gelatinase B it was (65.23 ± 3.62)%, (82.49 ± 2.88)% and (47.32 ± 7.72)%, respectively. Conclusions The expression and activities of gelatinases are downregulated in the endothelial cells when incubated with ATRA, which may be the possible mechanism of ATRA inhibiting the endothelial cell migration elicited by PMA in vitro." @default.
- W2373956858 created "2016-06-24" @default.
- W2373956858 creator A5069454979 @default.
- W2373956858 date "2004-01-01" @default.
- W2373956858 modified "2023-09-23" @default.
- W2373956858 title "All-Trans-Retinoid Effecting Endothelial Cell Migration and Gelatinase Expression" @default.
- W2373956858 hasPublicationYear "2004" @default.
- W2373956858 type Work @default.
- W2373956858 sameAs 2373956858 @default.
- W2373956858 citedByCount "0" @default.
- W2373956858 crossrefType "journal-article" @default.
- W2373956858 hasAuthorship W2373956858A5069454979 @default.
- W2373956858 hasConcept C104317684 @default.
- W2373956858 hasConcept C109523444 @default.
- W2373956858 hasConcept C123012128 @default.
- W2373956858 hasConcept C153911025 @default.
- W2373956858 hasConcept C177430391 @default.
- W2373956858 hasConcept C185592680 @default.
- W2373956858 hasConcept C202751555 @default.
- W2373956858 hasConcept C2775954498 @default.
- W2373956858 hasConcept C2776223131 @default.
- W2373956858 hasConcept C2776232661 @default.
- W2373956858 hasConcept C2776415932 @default.
- W2373956858 hasConcept C2781121885 @default.
- W2373956858 hasConcept C2910246616 @default.
- W2373956858 hasConcept C55493867 @default.
- W2373956858 hasConcept C86803240 @default.
- W2373956858 hasConceptScore W2373956858C104317684 @default.
- W2373956858 hasConceptScore W2373956858C109523444 @default.
- W2373956858 hasConceptScore W2373956858C123012128 @default.
- W2373956858 hasConceptScore W2373956858C153911025 @default.
- W2373956858 hasConceptScore W2373956858C177430391 @default.
- W2373956858 hasConceptScore W2373956858C185592680 @default.
- W2373956858 hasConceptScore W2373956858C202751555 @default.
- W2373956858 hasConceptScore W2373956858C2775954498 @default.
- W2373956858 hasConceptScore W2373956858C2776223131 @default.
- W2373956858 hasConceptScore W2373956858C2776232661 @default.
- W2373956858 hasConceptScore W2373956858C2776415932 @default.
- W2373956858 hasConceptScore W2373956858C2781121885 @default.
- W2373956858 hasConceptScore W2373956858C2910246616 @default.
- W2373956858 hasConceptScore W2373956858C55493867 @default.
- W2373956858 hasConceptScore W2373956858C86803240 @default.
- W2373956858 hasLocation W23739568581 @default.
- W2373956858 hasOpenAccess W2373956858 @default.
- W2373956858 hasPrimaryLocation W23739568581 @default.
- W2373956858 hasRelatedWork W1968327473 @default.
- W2373956858 hasRelatedWork W2030029073 @default.
- W2373956858 hasRelatedWork W2031297495 @default.
- W2373956858 hasRelatedWork W2096818461 @default.
- W2373956858 hasRelatedWork W2113088538 @default.
- W2373956858 hasRelatedWork W2144191439 @default.
- W2373956858 hasRelatedWork W2354417070 @default.
- W2373956858 hasRelatedWork W2356213330 @default.
- W2373956858 hasRelatedWork W2370436472 @default.
- W2373956858 hasRelatedWork W2371517649 @default.
- W2373956858 hasRelatedWork W2378301620 @default.
- W2373956858 hasRelatedWork W2381203369 @default.
- W2373956858 hasRelatedWork W2382472490 @default.
- W2373956858 hasRelatedWork W2382495715 @default.
- W2373956858 hasRelatedWork W2387568148 @default.
- W2373956858 hasRelatedWork W2388032000 @default.
- W2373956858 hasRelatedWork W297847554 @default.
- W2373956858 hasRelatedWork W3030759541 @default.
- W2373956858 hasRelatedWork W3031872304 @default.
- W2373956858 hasRelatedWork W2614113810 @default.
- W2373956858 isParatext "false" @default.
- W2373956858 isRetracted "false" @default.
- W2373956858 magId "2373956858" @default.
- W2373956858 workType "article" @default.