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- W2373967323 abstract "【Objective】 The aim of this study was to investigate the effect of Aroclor 1254 on mouse embryo(2-cell and 8-cell stage) development in vitro.【Method】 Aroclor 1254 of 0.05,0.25,1.25 and 6.25 μg/mL were added to the mouse embryo(2-cell and 8-cell stage) culture media respectively,solvent(ethanol) control group and blank control group were set and then the effects of Aroclor 1254 with different concentration to the mouse embryo developmental competence cultured in vitro were compared.【Result】 The results indicated that Aroclor 1254 with 0.05 μg/mL could significantly depress the hatching rate(57.7%) of the 2-cell stage embryos compared with the solvent control group(66.7%)(P0.05);The blastular ratio(72.5%) and hatching rate(23.2%) were degraded significantly at 0.25 μg/mL of Aroclor 1254 compared with that of corresponding solvent control group(84.2%,66.7%,respectively)(P0.01);When the concentration og Aroclor 1254 elevated to 1.25 μg/mL,the embryo developmental proportion from 2-cell to 8-cell stage(32.1%) was notably cut down compared with that of the dissolvent control group.And the ratio of 2-cell stage embryos development to the 4-cell and 8-cell stage(58.1% and 29.6% respectively) were significantly lower than that of dissolvent control group(P0.01),after the 2-cell stage embryos were exposed to Arcolor 1254 of 6.25 μg/mL.Aroclor 1254 at 0.05 μg/mL had no significant impact on the developmental competence of 8-cell embryos,but when the concentration was elevated to 0.25 μg/mL,the hatching rate(64.7%) of the 8-cell embryos was significantly decreased,compared with that of the solvent control group(P0.05).The blastocyst developmental rate(68.6%) and hatching rate(25.5%) of the 8-cell embryos with 0.25 μg/mL of Aroclor 1254 were obviously lower than that of the corresponding solvent control group(92.4%,75.7%,respectively)(P0.01).No embryo can develop continously when the concentration of Aroclor 1254 was evaluated to 6.25 μg/mL.【Conclusion】 The conclusion was that Aroclor 1254 depressed the mouse embryo development according to the dose-toxicity in vitro;as the dose of Aroclor 1254 increased,the toxical effect on mouse embryo development would appear earlier and act more fiercely.The younger the embryo was,the more sensitive it was to Aroclor 1254." @default.
- W2373967323 created "2016-06-24" @default.
- W2373967323 creator A5024712968 @default.
- W2373967323 date "2008-01-01" @default.
- W2373967323 modified "2023-09-23" @default.
- W2373967323 title "Effect of Aroclor 1254 on early mouse embryo development in vitro" @default.
- W2373967323 hasPublicationYear "2008" @default.
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