Matches in SemOpenAlex for { <https://semopenalex.org/work/W2373970605> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2373970605 abstract "Objectives To use bioinformatics software to predict and screen HLA-A*0201 restricted CD8+CTL epitopes in Mycobacterium tuberculosis(Mtb).Methods H37Rv,a reference Mtb strain,and the Beijing genotype were studied.The Mtb whole genome array was used to screen genes that were up-regulated under anaerobic cultivation.The online database SYFPEITHI was used to predict potential HLA-A*0201 restricted CD8+CTL epitopes.A T2 cell line was used to determine the affinity and stability of the predicted epitope peptides and HLA-A*0201 was used to screen HLA-A*0201 CD8+CTL epitopes.Results Four potential epitopes were identified from the epitope peptides predicted by the SYFPEITHI database.A T2 binding affinity assay indicated that 3 of the 4 peptides(Rv0440-1,Rv0440-9,and Rv0350-6) had high binding affinity for HLA-A*0201 molecules(FR1.5).A T2 stabilization assay indicated that Rv0440-1 and Rv0440-9 bound stably to HLA-A*0201 molecules(DC504 h).Conclusion Bioinformatics software and an assay of HLA-A2 binding and dissociation identified Rv0440-1(KLAGGVAVI)and Rv0440-9(TLLKGAKEV) as HLA-A*0201 restricted CD8+CTL epitopes of latent-phase Mtb.These results should be further verified by additional experiments." @default.
- W2373970605 created "2016-06-24" @default.
- W2373970605 creator A5028646150 @default.
- W2373970605 date "2013-01-01" @default.
- W2373970605 modified "2023-09-23" @default.
- W2373970605 title "High-throughput screening of HLA-A~*0201 restricted CD8~+CTL epitopes in latent-phase Mycobacterium tuberculosis(Mtb)" @default.
- W2373970605 hasPublicationYear "2013" @default.
- W2373970605 type Work @default.
- W2373970605 sameAs 2373970605 @default.
- W2373970605 citedByCount "0" @default.
- W2373970605 crossrefType "journal-article" @default.
- W2373970605 hasAuthorship W2373970605A5028646150 @default.
- W2373970605 hasConcept C142724271 @default.
- W2373970605 hasConcept C147483822 @default.
- W2373970605 hasConcept C147969180 @default.
- W2373970605 hasConcept C153911025 @default.
- W2373970605 hasConcept C159047783 @default.
- W2373970605 hasConcept C167672396 @default.
- W2373970605 hasConcept C188280979 @default.
- W2373970605 hasConcept C195616568 @default.
- W2373970605 hasConcept C2777975735 @default.
- W2373970605 hasConcept C2781069245 @default.
- W2373970605 hasConcept C54355233 @default.
- W2373970605 hasConcept C71924100 @default.
- W2373970605 hasConcept C86803240 @default.
- W2373970605 hasConcept C8891405 @default.
- W2373970605 hasConceptScore W2373970605C142724271 @default.
- W2373970605 hasConceptScore W2373970605C147483822 @default.
- W2373970605 hasConceptScore W2373970605C147969180 @default.
- W2373970605 hasConceptScore W2373970605C153911025 @default.
- W2373970605 hasConceptScore W2373970605C159047783 @default.
- W2373970605 hasConceptScore W2373970605C167672396 @default.
- W2373970605 hasConceptScore W2373970605C188280979 @default.
- W2373970605 hasConceptScore W2373970605C195616568 @default.
- W2373970605 hasConceptScore W2373970605C2777975735 @default.
- W2373970605 hasConceptScore W2373970605C2781069245 @default.
- W2373970605 hasConceptScore W2373970605C54355233 @default.
- W2373970605 hasConceptScore W2373970605C71924100 @default.
- W2373970605 hasConceptScore W2373970605C86803240 @default.
- W2373970605 hasConceptScore W2373970605C8891405 @default.
- W2373970605 hasOpenAccess W2373970605 @default.
- W2373970605 hasRelatedWork W200388417 @default.
- W2373970605 hasRelatedWork W2009124598 @default.
- W2373970605 hasRelatedWork W2042285023 @default.
- W2373970605 hasRelatedWork W2060512878 @default.
- W2373970605 hasRelatedWork W2063071953 @default.
- W2373970605 hasRelatedWork W2104421244 @default.
- W2373970605 hasRelatedWork W2350161080 @default.
- W2373970605 hasRelatedWork W2353450308 @default.
- W2373970605 hasRelatedWork W2358887858 @default.
- W2373970605 hasRelatedWork W2373016530 @default.
- W2373970605 hasRelatedWork W2374407640 @default.
- W2373970605 hasRelatedWork W2377807061 @default.
- W2373970605 hasRelatedWork W2384688122 @default.
- W2373970605 hasRelatedWork W2393794097 @default.
- W2373970605 hasRelatedWork W2750089919 @default.
- W2373970605 hasRelatedWork W3010425272 @default.
- W2373970605 hasRelatedWork W3025759100 @default.
- W2373970605 hasRelatedWork W3143831432 @default.
- W2373970605 hasRelatedWork W3191443162 @default.
- W2373970605 hasRelatedWork W2768543426 @default.
- W2373970605 isParatext "false" @default.
- W2373970605 isRetracted "false" @default.
- W2373970605 magId "2373970605" @default.
- W2373970605 workType "article" @default.