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- W2373978257 abstract "Objective To evaluate the safety and efficacy of botulinum toxin type A for injection(BTXA) in treatment of glabellar lines.Methods A multiple-dose,multicenter,randomized,double-blind,placebo-controlled,parallel-group superiority trial of the efficacy and safety of BTXA in the treatment of glabellar lines was conducted.Placebo,BTXA 100 U/vial and BTXA 50 U/vial were solubilized with 2.5 mL of sodium chloride injection resoectively,and injected 0.1 mL to each 5 specific and distinct sites for each subjects,2 on both left and right frown muscle,and 1 on drop glabella muscle.Results According to the investigation to 488 subjects during 120 days,efficacy measurement showed that the glabellar line reduction was significantly higher in high BTXA dose(20 U) group than in low dose(10 U) group,and in low dose(10 U) group than in placebo groups.The safety measurement showed 81 subjects and 138 incidents adverse events,69 subjects and 81 incidents adverse reaction,and no severe adverse events.Conclusion BTXA injections(10 U,20U) are safe,and effective in reducing the glabellar lines comparing to placebo.The effect in high BTXA dose group(20 U) was greater than low dose group(10 U),but there were no significant difference in the events and rates of adverse reactions between these two groups." @default.
- W2373978257 created "2016-06-24" @default.
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- W2373978257 date "2012-01-01" @default.
- W2373978257 modified "2023-10-14" @default.
- W2373978257 title "The safety and efficacy of botulinum toxin type A for injectionin the treatment of glabellar lines" @default.
- W2373978257 hasPublicationYear "2012" @default.
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