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- W2373981207 abstract "Objective To study the dose-effectiveness of intranasal(IN) vascular endothelial growth factor(VEGF)in focal cerebral ischemia/reperfusion injury of rats.Methods Sprague-Dawley rats were randomized into four groups as IN low(100 μg/mL),IN middle(200 μg/mL) and IN high(500 μg/mL) VEGF-treated group,and IN saline-treated group(n=12),given recombinant human VEGF or saline intranasally.Focal cerebral ischemia/reperfusion was induced by transient(90 minutes) middle cerebral artery occlusion(MCAO) method.Behavioral neurological deficits were assessed 1 d,7 d and 14 d after the onset of MCAO.Rats were euthanized at 14 d,the brain sections were stained and an image analysis system was used to calculate the infarct volume and calculated the number of cerebral vessels.Results Compared to IN saline,infarct volume after MCAO significantly reduced(P0.01) in rats which received the middle(200 μg/mL) dose of IN VEGF.VEGF with middle dose significantly improved behavioral recovery(P0.01).No significant differences in behavioral recovery and infarct volume after MCAO were seen between the IN saline group and in low and high VEGF-treated group(P0.05).Compared to IN saline,VEGF with middle and high dose significantly increased the number of cerebral vessels(P0.01).No significant differences in the number of cerebral vessels were seen between the IN saline group and low VEGF-treated group(P0.05).Conclusion The middle dose(200 μg/mL)of IN VEGF was most effective at reducing infarct volume,improving behavioral recovery and increasing the number of vessels,which can be used in the following treatments to further evaluate the effect of VEGF." @default.
- W2373981207 created "2016-06-24" @default.
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- W2373981207 date "2009-01-01" @default.
- W2373981207 modified "2023-09-26" @default.
- W2373981207 title "The dose-effectiveness of intranasal VEGF in focal cerebral ischemia/reperfusion injury of rats" @default.
- W2373981207 hasPublicationYear "2009" @default.
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