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- W2373981781 abstract "Objective To explore clinical significance of E-cadherin(E-cd),p16 and Ki-67 expressions in human glioma.Methods Expressions of E-cd,p16 and Ki-67 were detected in 53 cases of glioma and 12 cases of normal brain tissue by means of immunohistochemistry.Results The positive expression rates of E-cd and p16 in normal brain tissue (100%) were significantly higher than those in the gliomas. The positive expression rate of E-cd in the gliomas of gradesⅠ-Ⅱ(53.6%)was significantly higher than that in the gliomas of gradesⅢ-Ⅳ(20.0%) (P0.05).The positive expression rate of p16 in the gliomas of gradesⅠ-Ⅱ(57.1%)was significantly higher than that in the gliomas of gradesⅢ-Ⅳ(24.0%) (P 0.05);and the expresion of E-cd was positively correlated to that of p16 in the gliomas (P0.05).The expression of Ki67 were also seen in all kinds of gliomas, but the positive cells (frame 1%-30%)varied significantly between different grades (P0.01).Conclusion E-cd,p16 and Ki-67 could play an important roles in the pathogenesis and development of the gliomas and they are helpful to evaluate prognosis of patients with gliomas." @default.
- W2373981781 created "2016-06-24" @default.
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- W2373981781 date "2006-01-01" @default.
- W2373981781 modified "2023-09-25" @default.
- W2373981781 title "Expression of E-cadherin,p16 and Ki-67 in human glioma and their significances" @default.
- W2373981781 hasPublicationYear "2006" @default.
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