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- W2373983645 abstract "Objective To investigate the abilities of the learning and memory in temporal lobe epileptic rats and its relationship with the expression of PSD-95.Methods Forty male Wistar rats were divided randomly into kainic acid(KA) group and control group.The KA group was made by KA through intraperitoneal injection and the control group by normal saline(NS).According to developing spontaneous recurrent seizure(SRS),the KA group was divided into KA+SRS group(group A) and KA-SRS group(group B).The control group was group C.Then the learning and memory abilities of rats were tested by water maze training at 2 and 6 weeks after using KA or NS.The histopathology of hippocampus of different groups were observed by HE staining.The expression levels of PSD-95 in hippocampus of the rats of different groups were compared by immunohistochemical staining.Results No extensive neuronal cell loss and gliosis were noted,and areas of neuronal cell loss and gliosis were occasionally seen in hippocampus at 6 weeks after using KA.No neuronal cell loss and gliosis were noted in hippocampus at 6 weeks after using NS.Compared with those of group A at 2 weeks,and of group B,C at 2 and 6 weeks,the learning and memory abilities of group A at 6 weeks were obviously impaired(P0.01),and the expression of PSD-95 of group A in hippocampus decreased(P0.05).Conclusions The decrease of expression of PSD-95 in hippocampus might result in impairments of learning and memory abilities of temporal lobe epileptic rats." @default.
- W2373983645 created "2016-06-24" @default.
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- W2373983645 date "2009-01-01" @default.
- W2373983645 modified "2023-09-24" @default.
- W2373983645 title "Relationship between deficits for learning memory in temporal lobe rats and expressions of PSD-95 in hippocampus" @default.
- W2373983645 hasPublicationYear "2009" @default.
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