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- W2374001986 abstract "Objective To determine the protective effects of three kinds of the domestic fibrinolytic agents on cerebral ischemia/reperfusion injur in rats. Methods Using the focal cerebral ischemia/reperfusion model of rats,the protective effects of three kinds of the domestic fibrinolytic agents on the injury of ischemia/reperfusion of various periods were assessed by determining of the area of infarction,the volume of cerebral blood flow,the neurologic deficit score and the rate of macroscopic bleeding in the region of infarction. Results On the areas of cerebral infarction in the rats of persistent ischemia for 3h and of ischemia for 3h/reperfusion for 6h and 24h,the animals administrated by the domestic fibrinolytic agents were less than that of the animals administrated by saline(P(0.05)),but were not much different in the rats of cerebral ischemia for 3h/reperfusion for 3h and 72h between the rats administrated by saline and the domestic fibrinolytic agents(P0.05). The volumes of cerebral blood flow in the rats of ischemia for 3h/reperfusion for 6h,24h or 72h,the animals administrated by the domestic fibrinolytic agents were significantly increased,compared to the ones treated by saline,except for the rats of ischemia for 3h/reperfusion for 3h. But the neurologic deficit score in the all rats administrated by the fibrinolytic agents were not improved accordingly,compared to the animals treated by saline.The rats administrated by the fibrinolytic agents had no statistical more amount of macroscopic bleeding in region of infarction than the animals administrated by saline. Conclusion The domestic fibrinolytic agents can significantly decrease the area of infarction and increase the volume of cerebral blood flow as well as improve the low perfusion state after cerebral infarction. Thereby,it is benificial to reduction of the ischemic/reperfusion brain injury." @default.
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- W2374001986 date "2005-01-01" @default.
- W2374001986 modified "2023-09-24" @default.
- W2374001986 title "Protective effects of the domestic fibrinolytic agents on cerebral ischemia/ reperfusion injured rats" @default.
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