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- W2374021760 abstract "Objective:To investigate the expression of endothelial nitric oxide synthase traffic inducer (NOSTRIN) induced by umbilical serum in cultured human umbilical vein endothelial cell (HUVEC) and the regulation mechnism of ligustrazine in the process.Methods:The cultured HUVECs from women with preeclampsia and normal pregnant women were treated by ligustrazine for 30 minutes and incubated for 48 hours with medium containing 20% serum. MTT was used to determine the cell activity, reverse transcription-polymerase chain reaction (PT-PCR) was used to detect the expression of NOSTRIN.Results:The cell activity of HUVEC in preeclampsia women (0.131 8±0.031) was significantly lower than that in normal women (0.192 9±0.055) (P0.05).The expressive quantity of NOSTIN mRNA in preeclampsia women (0.493±0.057) was significantly higher than that in normal women (0.202±0.031) (P0.01).When treated by ligustrazine, the cell activity in preeclampsia women (0.186 4±0.041) was significantly higher than that in normal women (P0.01).The expressive level of NOSTIN mRNA in preeclampsia women (0.273±0.048) was significantly lower than that in normal women (P0.01).Conclusion:Umbilical serum can up-regulate the expression of NOSTRIN gene in HUVEC, ligustrazine can inhibit the overexpression of NOSTRIN induced by umbilical serum. Ligustrazine plays a role in the prevention and therapy of preeclampsia women." @default.
- W2374021760 created "2016-06-24" @default.
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- W2374021760 date "2009-01-01" @default.
- W2374021760 modified "2023-09-22" @default.
- W2374021760 title "Inhibitory effect of ligustrazine on the expression of NOSTRIN induced by umbilical serum of preeclampsia in cultured human umbilical vein endothelial cell." @default.
- W2374021760 hasPublicationYear "2009" @default.
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