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- W2374025145 abstract "To investigate T cell subsets and the expression of costimulatory molecule in peripheral blood mononuclear cells(PBMC) of patients with Graves' disease(GD) and its role on pathogenesis of GD,the T cell subsets and expression of costimulatory molecule in 19 GD patients were analyzed by using immunophenotyping and flowcytometry. The experimental results showed that CD3 + and CD4 + T cells decreased significantly(P0.05) and the ratio of CD4 +/CD8 +T cell was reversed in active GD patients;the expression of CD28 on T cells was remarkably lower compared to that of normal controls(P0.01);both CD4 +CD28 +?CD8 +CD28 + T cells in PBMC reduced significantly(P0.05,P0.01) while the high expression of 4-1BB was presented than those in controls(P0.05). After effective treatment,T cell subsets and the expression of CD28 and 4-1BB tended to return to normal(P0.01) and CD4 +CD28 +?CD8 +CD28 + T cells increased(P0.01). Thyroid autoantibody,such as TGAb and TMAb,also decreased correlatively(P0.01,P0.01). It concludes that abnormal T cell subsets and CD28 and 4-1BB costimulatory molecule play an important role in pathogenesis and development of GD." @default.
- W2374025145 created "2016-06-24" @default.
- W2374025145 creator A5071151975 @default.
- W2374025145 date "2002-01-01" @default.
- W2374025145 modified "2023-09-25" @default.
- W2374025145 title "Significance of T Cell Subsets and Expression of Costimulatory Molecule in Peripheral Blood of Patients with Graves' Disease and its Implication on Clinical Outcome" @default.
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