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- W2374028984 abstract "Objective To research the efficacy and ovarian toxicity of IVCTX in lupus nephritis patients.Method Sixty six patients with lupus nephritis were treated with pulse intra venus cyclophosphamide (CTX(0 5～1 0)g/m 2 monthly,for 6～12 months).Proteinuria.renal function and sex hormone level etc.were tested.Results The mean proteinuria was decreased from (4 54±2 98)g/d to (1 49±1 26)g/d,59(89 4%) patients were responsive to the therapy.After 1 to 9 year (average 4 3 year) follow up,63 (96 9%) maintained serum creatinine level 140 μmol/L.Sever (14 9%) of 47 premenopausal women were with amenorrhea for more than 6 months after the IVCTX therapy.Thirteen women were tested for sex hormone levels (LH,FSH,E 2,P) Two of them had no peak change of progestin during luteal stage,and in of the 2 the menpause appeared 2 months later.Conclusion IVCTX therapy in LN very effective,the responsible ratio may be 86 4%;The side effects of IVCTX can be well tolerated.Testing progestin in luternal stage may be helpful to find toxicity of IVCTX on ovarian." @default.
- W2374028984 created "2016-06-24" @default.
- W2374028984 creator A5052097195 @default.
- W2374028984 date "2000-01-01" @default.
- W2374028984 modified "2023-09-28" @default.
- W2374028984 title "Long term follow up of lupus nephritis patients treated with IVCTX" @default.
- W2374028984 hasPublicationYear "2000" @default.
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