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- W2374038086 abstract "Objective:To establish modles of rat ischemia preconditioning(I /P) and ischemia reperfusion(I/R) and to study the changes of I kappB kinaseβ(IKKβ) and Neutrophil Gelatinase-Associated Lipocalin(NGAL).Method:Thirty male Sprague-Dawley rats were divided into 3 groups randomly after right kidney nephrectomy.Group A was sham-operated control.Group B rats were 45-minutes ischemic in the left renal artery while Group C rats were pretreatmented with 3 cycles of 2-minutes ischemia and 5-minutes reperfusion.All the rats were sacrificed at 24 h after reperfusion.We harvested kidneys and serum to do further analysis,including histological and functional parameters,expressions of NGAL and IKKβ in renal tissues.Results:Compared with rats suffered from is-chemia-reperfusion injury,pretreatmented rats had a significant decrease in serum creatinine level and tubulointerstitial injury scores.In addition,expressions of IKKβ and NGAL at renal tubule were attenuated significantly.Moreover,our study showed IKKβ and NGAL were in positive correlation.Conclusion:IKKβ plays roles in renal ischemia-reperfusion injury,give rise to the generation of NGAL.IKKβ inhibition in ischemia preconditioning attenuates renal injury and the espression of NGAL following acute ischemia-reperfusion injury" @default.
- W2374038086 created "2016-06-24" @default.
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- W2374038086 date "2009-01-01" @default.
- W2374038086 modified "2023-09-23" @default.
- W2374038086 title "The preliminary study about the changes and significance of IKKβ generated in renal acute ischemic injury" @default.
- W2374038086 hasPublicationYear "2009" @default.
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