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- W2374062829 abstract "Objective To investigate the mechanisms of oxidative injury and apoptosis in PN associated hepatic dysfunction and the possible effectiveness of Danshen (a traditional Chinese medicine) to alleviate this injury. Methods Thirty New Zealand rabbits (6-8days old, Wt 80-110g) were divided into 3 groups: 10 in control group (breast fed); 10 in PN group (PN for 10 days); 10 in Danshen+ PN group (PN plus Danshen for 10 days). After 10 days, blood biochemistry analysis was performed, the liver histological changes were examined by light scope and electric scope, and the malondialdehyde (MDA) content of liver tissues and TUNEL positive hepatocytes were also determined.Results The serum concentrations of direct bilirubin and bile acid in PN group were significantly higher than those in the control group and Danshen + PN group (P0. 05). Compared with the obvious cholestatic changes or hepatic steatosis in the PN group, no obvious cholestatic or steatosis changes could be found in the Danshen+ PN group. The histological scores were 8, 22, and 15 in control, PN and PN + Danshen group, respectively. The results of electron microscopy were consistent with the light microscopical findings. MDA value in PN-group was higher than that in the control group (2. 04±0. 44 vs 1.35±0.29. P0. 05) and in the Danshen-PN group (2.04±0.44 vs 1.19±0.14,P0.05). TUNEL assay showed the positive rate of apoptotic hepatocytes in PN group was the highest among these 3 groups. Conclusions Danshen can reduce hepatocyte apoptosis caused by PN via its' anti-oxi-dative and anti-apoptotic effects." @default.
- W2374062829 created "2016-06-24" @default.
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- W2374062829 date "2006-01-01" @default.
- W2374062829 modified "2023-09-24" @default.
- W2374062829 title "Danshen decreases hepatocyte injury induced by PN in neonatal rabbits" @default.
- W2374062829 hasPublicationYear "2006" @default.
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