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- W2374070101 abstract "Objective To investigate the distribution of pathogens and variation of drug resistance in preterm infants infected by bacterias,for the purpose of prevention of preterm infections and guidance of clinical medication.Methods Samples of blood,sputum and umbilical part et al,from the infected preterm infants admitted to our neonatal intensive care unit from October 1997 to October 2007 were cultured and susceptibility tested.Results ①Of the total 733 isolated pathogenic strains,the isolates rate of Gram-negative bacillus was 65.35%,and the main pathogens were Klebsiella pneumoniae,Escherichia coli and Pseudomonas aeruginosa.The isolates rate of Gram-positive coccus was 31.11%,and the main pathogens were Staphylococcus aureus,Staphylococcus epidermidis,and other coagulase negative staphylococcus;②75 strains(28.74%)from blood cultures were L-type bacterias.23.68%of the staphylococci were meticillin resistant.Among the Gram-negative bacillus,the detection rate of Entended spectrum beta-lactamase producing strains(ESBLs),AmpC beta-lactamases,and super spectrum beta-lactamases(SSBL),were 22.00%,1.28%and 0.85%,respectively;③The resistance rates of Gram-positive coccus to penicillins and macrolide antibiotics were higher than 50.00%,but were low to vancomycin and piperacillin/tazobactam.The resistance rates of Gram-negative bacillu to archi-cephem and tert-cephem antibiotic were higher than 50.00%,and were low to tetra-cephalosporins,carbopenems,β-lactam antibiotics plus enzyme inhibitor.The resistance rates of Stenotrophomonas maltophilia to imipenem were 100%,but were low to cefoperazone/sulbactam,ciprofloxacin,piperacillin/tazobactam.Conclusion ①The main pathogens of bacterial infection in preterm infants were Gram-negative bacillus,and the drug resistances of pathogens were increased during the last ten years;②More attention should be paid to the opportunistic infection by coagulase negative staphylococcus,Pseudomonas aeruginosa and Stenotrophomonas maltophilia;③We should chose sensitive antibiotics according to the susceptibility test to decrease multidrug resistant strains." @default.
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- W2374070101 title "The distribution of pathogens and variation of drug resistance in bacterial infection of preterm infants" @default.
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