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- W2374080605 abstract "OBJECTIVE To examine whether the material and its metabolites have an impact on the surrounding tissue and test whether its biocompatibility is good or not.METHODS In vitro cytotoxicity test was performed,MTT Test Group: the mouse osteoblasts was adopted to make cell suspension with different concentrations of MPC extract and observed for 1,3 and 5 days by adding MTT,DMSO,the absorbance was measured and the cell relative growth rate(RGR) was calculated,and toxicity was graded.ALP Test: the mouse osteoblasts was adopted to make cell suspension with different concentrations of MPC extract for the study group,phenol standard solution was selected as the standard group,double-distilled water was as a blank control group,normal 10% DMEM cell culture medium as negative the control group.After the observation for 1,3,5 days,alkaline phosphatase was used to detect,the light absorption value of phenol content was calculated.Inflammatory cytokine expression tests: the mouse osteoblasts and the producing cell suspension of different concentrations of MPC were mixed as a pilot group of extracts,cell culture medium was used as negative control,the ELISA of inflammatory factors of IL-1β,IL-6 and TNF-α were determinated by double antibody sandwich after the observation for1,3 and 5 days.RESULTS MTT test showed cell toxicity gradings were 0~1;different concentrations of MPC leaching solution had no effect on cell growth;ALP detection tests: different concentrations of MPC extract had no statistically significant differences;Inflammatory cytokine expression test: different concentrations of MPC extracts were compared with the negative control group,there was no statistically significant difference,which showed the molecular level would not promote the expression of inflammatory factors.CONCLUSIONS Magnesium phosphate cement on the osteoblast cells has no significant impact on the cells and no significant toxicity,but has a good cell compatibility.Magnesium phosphate cement in the cellular and molecular level will not promote the expression of inflammatory factors and induce the inflammatory response." @default.
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- W2374080605 date "2011-01-01" @default.
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- W2374080605 title "Biological safety of magnesium phosphate bone cement" @default.
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