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- W2374088149 abstract "Objective To develop a method for determining the entrapment efficiency of glycyrrhetinic acid-tanshinone IIA compound liposomes(GT-Lip).Methods Sephadex filtration and low-speed centrifugation were used for separating GT-Lip and free drugs.The determination results of these two methods for the entrapment efficiency were compared taken HPLC as analysis approach.Results Sephadex filtration G-50(M) absorbed some GT-Lip,which was not good for the determination of the entrapment efficiency of GT-Lip.The low-speed centrifugation separated effectively GT-Lip and free drugs,and the average entrapment efficiency of tanshinone IIA reached to(81.50 ±0.76)%and that of glycyrrhetinic acid reached to(98.63±0.90)%after HPLC determination.Conclusion HPLC combining low-speed centrifugation can applied for the effective determination of the entrapment efficiency of GT-Lip,which is quick and accurate." @default.
- W2374088149 created "2016-06-24" @default.
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- W2374088149 date "2013-01-01" @default.
- W2374088149 modified "2023-09-23" @default.
- W2374088149 title "Determination method for entrapment efficiency of glycyrrhetinic acidtanshinone IIA compound liposomes" @default.
- W2374088149 hasPublicationYear "2013" @default.
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