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- W2374089309 abstract "AIM:To assess the neuroprotective action of gastrodin on ischemic brain injury in vivo.METHODS:Gastrodin was intraperitoneally injected daily for 3 consecutive days starting 2 h after focal cerebral ischemia induction in SD rats by intraluminal occlusion of middle cerebral artery(MCAO).Apoptosis in the ischemic boundary zone was evaluated with TUNEL staining.Immunohistochemical techniques were used to analyze the S100β and iNOS expressions.RESULTS:Three days after MCAO,the number of TUNEL positive cells in gastrodin group was significantly decreased in the ischemic boundary zone(P0.05),and the numbers of S100β and iNOS positive cells were remarkably decreased as well(P0.05).CONCLUSION:Gastrodin injection could depress the apoptosis in a rat model of focal cerebral ischemia,suggesting that gastrodin has a neuroprotective effect on brain ischemia.Down-regulation of S100β and iNOS expressions is possibly associated with the inhibitory effect of gastrodin on apoptosis under ischemic conditions." @default.
- W2374089309 created "2016-06-24" @default.
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- W2374089309 date "2008-01-01" @default.
- W2374089309 modified "2023-09-22" @default.
- W2374089309 title "Neuroprotective effect of gastrodin on rat with transient middle cerebral artery occlusion" @default.
- W2374089309 hasPublicationYear "2008" @default.
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