Matches in SemOpenAlex for { <https://semopenalex.org/work/W237410942> ?p ?o ?g. }
- W237410942 endingPage "76" @default.
- W237410942 startingPage "49" @default.
- W237410942 abstract "Antibody–drug conjugates (ADCs) seek to exploit the desirable features of their components, i.e., specificity in targeting tumor cells and long half-life in plasma conferred by the antibody and the cytotoxic potency of the small effector molecule. A linker tethers the antibody to a cytotoxic agent, and allows stable circulation of the cytotoxin in the form of a prodrug. Many linkers have been designed over the years, which showcase features that are more than a mere physical linkage between the two constituent parts. Linkers can confer several advantages to ADCs, such as modulating the rate of cytotoxin release in tumor cells, overcoming multidrug resistance, enhancing tumor penetration, and a better safety profile in humans. This chapter highlights the progress made in linker technology, and how it impacts the design of optimal ADCs for clinical evaluation." @default.
- W237410942 created "2016-06-24" @default.
- W237410942 creator A5002328389 @default.
- W237410942 creator A5053289468 @default.
- W237410942 date "2015-01-01" @default.
- W237410942 modified "2023-09-23" @default.
- W237410942 title "Linker Design for Antibody–Drug Conjugates" @default.
- W237410942 cites W1519024299 @default.
- W237410942 cites W1795111525 @default.
- W237410942 cites W1891967301 @default.
- W237410942 cites W1967308690 @default.
- W237410942 cites W1971738718 @default.
- W237410942 cites W1973888120 @default.
- W237410942 cites W1977241343 @default.
- W237410942 cites W1977301054 @default.
- W237410942 cites W1979491356 @default.
- W237410942 cites W1981831440 @default.
- W237410942 cites W1983743199 @default.
- W237410942 cites W1988959629 @default.
- W237410942 cites W1991481467 @default.
- W237410942 cites W1992175481 @default.
- W237410942 cites W1995431674 @default.
- W237410942 cites W1997537633 @default.
- W237410942 cites W2000568282 @default.
- W237410942 cites W2003919149 @default.
- W237410942 cites W2004239570 @default.
- W237410942 cites W2008008775 @default.
- W237410942 cites W2008652440 @default.
- W237410942 cites W2011118089 @default.
- W237410942 cites W2024023279 @default.
- W237410942 cites W2024209769 @default.
- W237410942 cites W2024520647 @default.
- W237410942 cites W2025563156 @default.
- W237410942 cites W2030249962 @default.
- W237410942 cites W2031564862 @default.
- W237410942 cites W2032129634 @default.
- W237410942 cites W2042701817 @default.
- W237410942 cites W2045612610 @default.
- W237410942 cites W2046522614 @default.
- W237410942 cites W2050413161 @default.
- W237410942 cites W2053380672 @default.
- W237410942 cites W2055904567 @default.
- W237410942 cites W2055973049 @default.
- W237410942 cites W2060213126 @default.
- W237410942 cites W2065528643 @default.
- W237410942 cites W2078386415 @default.
- W237410942 cites W2079154601 @default.
- W237410942 cites W2083709832 @default.
- W237410942 cites W2090057677 @default.
- W237410942 cites W2093580676 @default.
- W237410942 cites W2099467058 @default.
- W237410942 cites W2113426218 @default.
- W237410942 cites W2114282952 @default.
- W237410942 cites W2116150122 @default.
- W237410942 cites W2124514746 @default.
- W237410942 cites W2126181165 @default.
- W237410942 cites W2126183505 @default.
- W237410942 cites W2132895530 @default.
- W237410942 cites W2136656832 @default.
- W237410942 cites W2143876351 @default.
- W237410942 cites W2150648608 @default.
- W237410942 cites W2154302491 @default.
- W237410942 cites W2164231501 @default.
- W237410942 cites W2166953979 @default.
- W237410942 cites W2170426247 @default.
- W237410942 cites W2301787994 @default.
- W237410942 cites W2321219061 @default.
- W237410942 cites W2324366850 @default.
- W237410942 cites W2398075684 @default.
- W237410942 cites W2560281006 @default.
- W237410942 doi "https://doi.org/10.1007/978-3-319-13081-1_4" @default.
- W237410942 hasPublicationYear "2015" @default.
- W237410942 type Work @default.
- W237410942 sameAs 237410942 @default.
- W237410942 citedByCount "1" @default.
- W237410942 countsByYear W2374109422020 @default.
- W237410942 crossrefType "book-chapter" @default.
- W237410942 hasAuthorship W237410942A5002328389 @default.
- W237410942 hasAuthorship W237410942A5053289468 @default.
- W237410942 hasConcept C134306372 @default.
- W237410942 hasConcept C159654299 @default.
- W237410942 hasConcept C185592680 @default.
- W237410942 hasConcept C197336794 @default.
- W237410942 hasConcept C199360897 @default.
- W237410942 hasConcept C203014093 @default.
- W237410942 hasConcept C21951064 @default.
- W237410942 hasConcept C2777325958 @default.
- W237410942 hasConcept C2780035454 @default.
- W237410942 hasConcept C2780557392 @default.
- W237410942 hasConcept C33923547 @default.
- W237410942 hasConcept C41008148 @default.
- W237410942 hasConcept C542903549 @default.
- W237410942 hasConcept C71924100 @default.
- W237410942 hasConcept C98274493 @default.
- W237410942 hasConceptScore W237410942C134306372 @default.
- W237410942 hasConceptScore W237410942C159654299 @default.
- W237410942 hasConceptScore W237410942C185592680 @default.
- W237410942 hasConceptScore W237410942C197336794 @default.