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- W2374111489 abstract "Objective To investigate the inhibitory action of aconitine on human Kv1.5(hKv1.5) channels expressed on Xenopus laevis oocytes. Methods hKv1.5 channels were expressed on Xenopus laevis oocytes and studied using two microelectrode voltage clamp technique. Results HKv1.5 channels could be stably expressed on Xenopus laevis oocytes. Aconitine produced a voltage-and time-dependent inhibition on hKv1.5 channels expressed on Xenopus laevis oocytes. Meanwhile,the inhibition on hKv1.5 channels was concentrition-dependent. The IC50 and Hill coefficient were 0.796±0.123 μmol/L and 0.280±0.020 respectively,and this action could be partly reversable. On the other hand,the suppresion action was frequncy-dependent. Conclusions Aconitine blocks hKv1.5 channel in a voltage-and time-and concentration-and frequncy-dependent fasion,futhermore,it inhibits the channels either in open or in inactive state. So it indicates that aonnitine may be an open state inhibiter of hKv1.5 potassium channels." @default.
- W2374111489 created "2016-06-24" @default.
- W2374111489 creator A5001128224 @default.
- W2374111489 date "2010-01-01" @default.
- W2374111489 modified "2023-09-25" @default.
- W2374111489 title "Electropharmacological properties of aconitine blocks on hKv1.5 potassium channels expressed on Xenopus laevis oocytes" @default.
- W2374111489 hasPublicationYear "2010" @default.
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