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- W2374130156 abstract "Objective To evaluate efficacy and safety of different dosages of recombined platelet derived growth factor- BB( r PDGF- BB) on chronic diabetic foot ulcer. Methods A total of 213 patients with chronic diabetic foot ulcer from 11 centers in China were enrolled and randomly divided into 3 groups after standard therapy: high dose group( n = 70),low dose group( n = 73) and control group( n = 70). Patients in high dose group and low dose group were given recombined platelet derived growth factor 100 μg·g- 1and 30 μg·g- 1,po. And patients in control group were given blank gel,po. The longest duration was 20 weeks. After therapy,the patients were followed every week at first 4 weeks then every 2weeks since then. The data of duration of heal,the reduction area of ulcer,recurrence rate of ulcer and adverse events were recorded andcompared. Results During 20 weeks therapy,the ratio of heal were 63. 77%( 44 /69),50. 68%( 37 /73),44. 93%( 31 /69) and the duration of heal were 5. 65,4. 90 and 4. 70 weeks in the high dose,low dose and control group,respectively( P 0. 05). The reduction area of ulcer were 90. 20%,89. 00%,95. 00% and recurrence rate of ulcer were 2. 27%( 1 /44),2. 70%( 1 /37),0( 0 /31) in the high dose,low dose and control group( P 0. 05). The incidence of adverse reaction in high dose,low dose and control group were 5. 80%,2. 74% and 2. 86%. One patient in high dose group was reported local pain which was related with drug,and there was no severe adverse event found in high and low dose group. But the incidence of serious adverse reaction in the control group was 1. 43%. Conclusion High dose of r PDGF- BB( 100 μg·g- 1) is effective and safe in treatment of chronic diabetic foot ulcer." @default.
- W2374130156 created "2016-06-24" @default.
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- W2374130156 date "2015-01-01" @default.
- W2374130156 modified "2023-09-27" @default.
- W2374130156 title "Efficacy and safety of recombined platelet derived growth factor-BB on chronic diabetic foot ulcer" @default.
- W2374130156 hasPublicationYear "2015" @default.
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