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- W2374141392 abstract "Objective To study the chemotaxis and invasion of breast cancer cells-MCF-7 facilitated by CC chemokine receptor-7(CCR7) and its ligand second lymphoid tissue chemokine(SLC) EBII-ligand chemokine(ELC).Methods The chemotaxis and invasion assays were performed on breast cancer cells-MCF-7 in presence of exogenous SLC and ELC.First detect the expression of SLC and ELC in novel lymph node with breast cancer metastasis by Westen-Blot.Second replace the exogenous SLC and ELC with the clear supernatant liquid of novel lymph node with breast cancer metastasis to study the chemotaxis and invasion of breast cancer cells-MCF-7 facilitated by endogenous SLC and ELC and when SLC and ELC was blocked.Results Both exotgenous and endogenous SLC and ELC can facilitate the chemotaxis and invasion of the breast cancer cells-MCF-7,both chemotaxis and invasion could be blocked by neutralazing anti-SLC,ELC antibody.Conclusion Chemotaxis and invasion of breast cance cell can be facilitated by axis of CCR7/SLC,ELC and the axis may play an important role in the lymph node metastasis of breast cancer." @default.
- W2374141392 created "2016-06-24" @default.
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- W2374141392 date "2011-01-01" @default.
- W2374141392 modified "2023-09-23" @default.
- W2374141392 title "CC chemokine receptor-7 and its ligand SLC,ELCS influence on chemotaxis and inyvasion of breast cancer cells" @default.
- W2374141392 hasPublicationYear "2011" @default.
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