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- W2374150906 abstract "Objective To investigate the expression level and its clinical significance of multidrug resistance(MDR) markers(P-gp,LRP and MRP) in lung squamous carcinoma and adenocarcinoma tissues.Methods The expression of lung cancer resistance protein(LRP),multidrug resistance protein(MRP) and P-glycoprotein(P-gp) of MDR markers were detected in 105 cases of lung cancer tissues by streptavidin-biotin-peroxidase(S-P) immunohistochemistry technique.Results There was overexpression of P-gp in the squamous carcinoma and adenocarcinoma tissues and the expression of P-gp in the adenocarcinoma(78.26%)was higher than that in the squamous cell carcinoma(47.46%)(P0.05).The expression of LRP in the adenocarcinoma(89.13%)was higher than that in the squamous carcinoma (44.07%)of lung(P0.01).No significance of difference was observed among the expression of MRP in different types of lung cancer(P0.05).Two kinds or more of MDR markers expression in the adenocarcinoma,squamous carcinoma were 89.13%,49.15%,respectively(P0.01).Conclusion It has different degree overexpression of multidrug resistant markers in squamous pulmonary carcinoma and adenocarcinoma tissues.Combined detection of P-gp,LRP and MRP may be useful for guiding the clinical chemotherapy of lung carcinoma." @default.
- W2374150906 created "2016-06-24" @default.
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- W2374150906 date "2006-01-01" @default.
- W2374150906 modified "2023-09-25" @default.
- W2374150906 title "Expression of Multidrug Resistance Markers in Lung Squamous Carcinoma and Adenocarcinoma Tissues" @default.
- W2374150906 hasPublicationYear "2006" @default.
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