FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2374157090> ?p ?o ?g. }

• W2374157090 abstract "Objective To investigate the hepatoprotective effects of Paeoniae Radix Rubra (PRR) at different doses against alpha-naphthylisothiocyanate (ANIT)-induced acute cholestatic hepatitis in rats. Methods Rats were ig admini- strated with vehicle or PRR ((1, 9, 18, 36, 54, 72, and 81 g/(kg·d)) 3 d before and 2 d after ANIT (60 mg/kg) ig administration. The general status of rats, histopathology of liver, serum alanine aminotransaminase, aspartate aminotransaminase, total bilirubin, direct bilirubin, and alkaline phosphatase levels, were observed at respective time points (24 and 48 h) after ANIT administration. Using cluster analysis and correspondence analysis, the dose-effect-response relationships of PRR were evaluated. Results The results showed that compared with model group, the serum biochemistry index significantly decreased with the increasing of PRR dosage (P < 0.01), and the change and necrosis of hepatic cellula, and inflammatory cell infiltration were gradually alleviated. However, the improvement was not obviously found in the low-dose group (1 g/(kg·d)). The cluster analysis and correspondence analysis results showed that different doses of PRR could significantly ameliorate ANIT-induced acute cholestatic hepatitis of rats in a dose-dependent manner. Conclusion The experiments show that administration doses of PRR in clinical use should be added properly in order to gain the expectant therapeutic effect, especially in the treatment of heavy acute cholestasis hepatitis." @default.
• W2374157090 created "2016-06-24" @default.
• W2374157090 creator A5010263218 @default.
• W2374157090 creator A5017388667 @default.
• W2374157090 creator A5018256092 @default.
• W2374157090 creator A5020761329 @default.
• W2374157090 creator A5032579515 @default.
• W2374157090 creator A5032719553 @default.
• W2374157090 creator A5032773676 @default.
• W2374157090 creator A5062736286 @default.
• W2374157090 creator A5077142060 @default.
• W2374157090 date "2011-01-01" @default.
• W2374157090 modified "2023-10-01" @default.
• W2374157090 title "Dose-Effect-Response Relationships of Paeoniae Radix Rubra on Alpha-Naphthylisothiocyanate-Induced Acute Cholestatic Hepatitis in Rats" @default.
• W2374157090 cites W1461936455 @default.
• W2374157090 cites W1528258582 @default.
• W2374157090 cites W1938519122 @default.
• W2374157090 cites W2005468255 @default.
• W2374157090 cites W2048559274 @default.
• W2374157090 cites W2056877663 @default.
• W2374157090 cites W2069512055 @default.
• W2374157090 cites W2075415807 @default.
• W2374157090 cites W2081600199 @default.
• W2374157090 cites W2115295760 @default.
• W2374157090 cites W2140815761 @default.
• W2374157090 cites W2273123250 @default.
• W2374157090 cites W2358961436 @default.
• W2374157090 cites W2369691206 @default.
• W2374157090 cites W2385655492 @default.
• W2374157090 cites W2411445781 @default.
• W2374157090 cites W2416046985 @default.
• W2374157090 cites W2883871681 @default.
• W2374157090 hasPublicationYear "2011" @default.
• W2374157090 type Work @default.
• W2374157090 sameAs 2374157090 @default.
• W2374157090 citedByCount "0" @default.
• W2374157090 crossrefType "journal-article" @default.
• W2374157090 hasAuthorship W2374157090A5010263218 @default.
• W2374157090 hasAuthorship W2374157090A5017388667 @default.
• W2374157090 hasAuthorship W2374157090A5018256092 @default.
• W2374157090 hasAuthorship W2374157090A5020761329 @default.
• W2374157090 hasAuthorship W2374157090A5032579515 @default.
• W2374157090 hasAuthorship W2374157090A5032719553 @default.
• W2374157090 hasAuthorship W2374157090A5032773676 @default.
• W2374157090 hasAuthorship W2374157090A5062736286 @default.
• W2374157090 hasAuthorship W2374157090A5077142060 @default.
• W2374157090 hasConcept C126322002 @default.
• W2374157090 hasConcept C142724271 @default.
• W2374157090 hasConcept C160160445 @default.
• W2374157090 hasConcept C181199279 @default.
• W2374157090 hasConcept C185592680 @default.
• W2374157090 hasConcept C203014093 @default.
• W2374157090 hasConcept C2776029263 @default.
• W2374157090 hasConcept C2776637226 @default.
• W2374157090 hasConcept C2777513400 @default.
• W2374157090 hasConcept C2778593092 @default.
• W2374157090 hasConcept C503630168 @default.
• W2374157090 hasConcept C544855455 @default.
• W2374157090 hasConcept C55493867 @default.
• W2374157090 hasConcept C71924100 @default.
• W2374157090 hasConcept C90924648 @default.
• W2374157090 hasConcept C98274493 @default.
• W2374157090 hasConceptScore W2374157090C126322002 @default.
• W2374157090 hasConceptScore W2374157090C142724271 @default.
• W2374157090 hasConceptScore W2374157090C160160445 @default.
• W2374157090 hasConceptScore W2374157090C181199279 @default.
• W2374157090 hasConceptScore W2374157090C185592680 @default.
• W2374157090 hasConceptScore W2374157090C203014093 @default.
• W2374157090 hasConceptScore W2374157090C2776029263 @default.
• W2374157090 hasConceptScore W2374157090C2776637226 @default.
• W2374157090 hasConceptScore W2374157090C2777513400 @default.
• W2374157090 hasConceptScore W2374157090C2778593092 @default.
• W2374157090 hasConceptScore W2374157090C503630168 @default.
• W2374157090 hasConceptScore W2374157090C544855455 @default.
• W2374157090 hasConceptScore W2374157090C55493867 @default.
• W2374157090 hasConceptScore W2374157090C71924100 @default.
• W2374157090 hasConceptScore W2374157090C90924648 @default.
• W2374157090 hasConceptScore W2374157090C98274493 @default.
• W2374157090 hasLocation W23741570901 @default.
• W2374157090 hasOpenAccess W2374157090 @default.
• W2374157090 hasPrimaryLocation W23741570901 @default.
• W2374157090 hasRelatedWork W1567365745 @default.
• W2374157090 hasRelatedWork W2068934287 @default.
• W2374157090 hasRelatedWork W2349984869 @default.
• W2374157090 hasRelatedWork W2355867149 @default.
• W2374157090 hasRelatedWork W2358158719 @default.
• W2374157090 hasRelatedWork W2363108161 @default.
• W2374157090 hasRelatedWork W2363344692 @default.
• W2374157090 hasRelatedWork W2363785730 @default.
• W2374157090 hasRelatedWork W2368727256 @default.
• W2374157090 hasRelatedWork W2372440548 @default.
• W2374157090 hasRelatedWork W2380971145 @default.
• W2374157090 hasRelatedWork W2382797167 @default.
• W2374157090 hasRelatedWork W2387051686 @default.
• W2374157090 hasRelatedWork W2582461494 @default.
• W2374157090 hasRelatedWork W2592351404 @default.
• W2374157090 hasRelatedWork W2890533040 @default.
• W2374157090 hasRelatedWork W2909314225 @default.
• W2374157090 hasRelatedWork W2935933559 @default.
• W2374157090 hasRelatedWork W814970103 @default.

• next