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- W2374178649 abstract "Objective:To investigate the expression of c-fos gene in crush lesion of peripheral nerve in early stage, and the protective mechanism of calcium channel blocker (CCB). Methods:Sciatic nerve was crushed by pincers to establish the model of sciatic nerve crush lesion in rats. The expression of c-fos gene and conductive rate of sciatic nerve were quantitated by immunohistochemistrical and electrophysiological techniques. SD rats were divided into normal group,pseudo-operation group, placebo control group, CCB (high-dose or low-dose Flunarizine) group at random. Results:The expression of c-fos gene in sciatic nerve was increased significantly on the first week after sciatic nerve crush lesion(P 0.01),and it was decreased by CCB significantly in the high-dose group(P 0.01). Conductive rate of sciatic nerve on the fourth week after sciatic nerve crush lesion was slower in CCB groups than that in normal group and pseudo-operation group, but higher than that in placebo control group(P 0.05). It was decreased by CCB in a dose-dependent manner(P 0.01). Conclusion: The expression of c-fos gene is increased significantly, which causes injury of nerve function in early stage of peripheral nerve crush lesion. CCB could decrease c-fos gene enpression by blocking Ca2+ internal flow. It shows that CCB has the protective action against peripheral nerve crush lesion." @default.
- W2374178649 created "2016-06-24" @default.
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- W2374178649 date "2006-01-01" @default.
- W2374178649 modified "2023-09-27" @default.
- W2374178649 title "Expression of c-fos gene in crush lesion of sciatic nerve and protection of Calcium channel blocker" @default.
- W2374178649 hasPublicationYear "2006" @default.
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