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- W2374192633 abstract "OBJECTIVE To study neurotransmitter changes in the auditory cortex(AC)of rat tinnitus model induced by salicylate for understanding the action of salicylate on the auditory system and the neurological mechanisms of salicylate-induced tinnitus.METHODS Twenty eight Wistar rats weighing 280～300 grams were randomly divided into saline treatment group(n=4),salicylate treatment group(n=12),and salicylate+lidocaine treatment group(n=12),Using in vivo microdialysis technique coupled with on-line electrochemical detection,the ascorbic acid release in AC was monitored and the effects of lidocaine on ascorbic acid changes in AC were examined in salicylate-induced tinnitus animal models.RESULTS Salicylate(350 mg/kg i.p.,n=12) produced an significant increase of ascorbic acid in the AC(up to 516%±162% of baseline).The increase of ascorbic acid level in salicylate + lidocaine group were significantly depressed in AC after local infusion(F=64.649,P0.001).In contrast,saline did not produce any significant changes.CONCLUSION The significant increase of AC ascorbic acid concentration after application of salicylate may be involved in tinnitus generation.The suppression of lidocaine to tinnitus may be associated with the depression of ascorbic acid level in AC in tinnitus generation." @default.
- W2374192633 created "2016-06-24" @default.
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- W2374192633 date "2013-01-01" @default.
- W2374192633 modified "2023-09-25" @default.
- W2374192633 title "Effects of lidocaine on ascorbic acid activities in auditory cortex of rat tinnitus model" @default.
- W2374192633 hasPublicationYear "2013" @default.
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