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- W2374193277 abstract "Objective To explore the expression of cytomegalovirus(CMV) antigen in the liver tissue of patients with chronic hepatitis B(CHB)and its clinical significance.Methods Seventy-six samples of liver tissues were detected by immunohistochemical staining with monoclonal anti-CMVAg,and these samples were stained by double labeling technique with polyclonal anti-HBcAg and monoclonal anti-CMV antibody to show the distribution of both HBV and CMV in CHB patients.Results There was no significant difference in positive rates of CMV between mild and severe chronic hepatitis(P=0.444),but the number of CMVAg positive cell in patients with severe CHB was markedly more than that of mild CHB(P=0.012).CMVAg was mainly found in the cytoplasm of hepatocytes.Double labeling technique shown that both of CMVAg and HBcAg expressed mainly in the same area of hepatic lobule even in same hepatocytes in most cases,but also in different part of hepatic lobule.Conclusion CHB patient is apt to develop superinfection of CMV, and the degree of CMV infection is closely correlated with active pathological changes in liver tissue." @default.
- W2374193277 created "2016-06-24" @default.
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- W2374193277 date "2006-01-01" @default.
- W2374193277 modified "2023-09-25" @default.
- W2374193277 title "Expression of cytomegalovirus in liver tissue from patient with chronic hepatitis B" @default.
- W2374193277 hasPublicationYear "2006" @default.
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