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- W2374209303 abstract "Objective:To investigate the effect of endotoxin on macrophage antigen presentation function in posttraumatic mice.Methods:Sixty Balb/c mice were injured by double femur fracture and soft tissue crash,endotoxin (1 mg/kg ) was injected intravenously on the first posttrauma day in the endotoxin group,while normal saline was injected in the control group.Macrophage Ⅰa expression was measured by flow cytometry and serum interleukin6(IL6) concentration was measured by enzymelinked immunosorbent assay(ELISA).Results:Macrophage Ⅰa antigen expression was markedly inhibited after trauma,it reached the lowest value on the first posttrauma day and returned gradually to normal range on the seventh posttrauma day.Endotoxin challenge further decreased the expression of Ⅰa antigens on macrophages,and it maintained a low level on the seventh posttrauma day.Serum IL6 concentration was obviously increased after trauma,it was much higher in the endotoxin group compared with controls.Conclusions:Endotoxin enhances the disturbance of macrophage antigen presentation function after trauma." @default.
- W2374209303 created "2016-06-24" @default.
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- W2374209303 date "2001-01-01" @default.
- W2374209303 modified "2023-09-28" @default.
- W2374209303 title "Effect of endotoxin on macrophage Ia antigen expression in traumatized mice" @default.
- W2374209303 hasPublicationYear "2001" @default.
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