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- W2374212496 abstract "Objective To identify factors that may predict steroid resistance through retrospectively analyzing the clinical data of steroid effective group and steroid resistant group,so as to play an important role to guide clinical treatment. Methods Two hundred and ten patients with UC in our hospital from January 1995 to May 2009 were studied. Their general data,clinical manifestation,usage of steroids,laboratory tests and endoscopic features were analyzed from the hospital records. According to therapeutic efficacy of steroids,patients were divided into steroid effective group, steroid resistant group and steroid dependent group. Univariate analysis and multivariate logistic regression analysis were done to the collected variables. Results In our study,the proportion of steroid resistant patients was 24. 7% in whom the steroids were used. In univariate analysis,male gender ( P = 0. 035) ,pancolitis ( P = 0. 00) ,albumin ( P = 0. 04) and severe disease according to Truelove and Witts graduation ( P =0. 00) were correlated with steroid resistance. In multivariate analysis,only male gender ( P =0. 035) and low albumin level ( P =0. 023) were shown to be statistically significant. Conclusion Male gender and low albumin level are predictive factors for steroid resistance in UC. The study of mechanism and predictive means of steroid resisitance in UC plays an important role in the treatment of these patients." @default.
- W2374212496 created "2016-06-24" @default.
- W2374212496 creator A5083090268 @default.
- W2374212496 date "2010-01-01" @default.
- W2374212496 modified "2023-09-26" @default.
- W2374212496 title "Predictive factors associated with steroid resistance in ulcerative colitis" @default.
- W2374212496 hasPublicationYear "2010" @default.
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