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- W2374218675 abstract "Objective To investigate the effect of dual blockade of rennin angiotensin system on tubulointerstitial fibrosis in diabetic nephropathy rats.Methods 60 STZ-induced diabetic nephropathy tats models were randomly divided into three groups: Normal control group(A group),group with Benazepril therapy(10 mg/kg B group),group with Benazepril(5 mg/kg)and Losartan(10 mg/kg)therapy(C group);At eight weeks after therapy,the expression of TGF-β1,CTGF and FN in tubulointerstitial were detected by immunohistochemistry and RT-PCR.Results Compared with A group and B group,the expression of TGF-β1,CTGF and FN were significantly down-regulated(P0.05 or P0.01) in tubulointerstitial of C group.Conclusion Dual blockade of RAS with intermediate dose ACEI and ARB is more effective in down-regulating the expression of TGF-β1,CTGF and FN in tubulointerstitial of diabetic nephropathy rats." @default.
- W2374218675 created "2016-06-24" @default.
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- W2374218675 date "2010-01-01" @default.
- W2374218675 modified "2023-09-26" @default.
- W2374218675 title "Effect of Dual Blockade of Renin Angiotensin System on Tubulointerstitial Fibrosis in Diabetic Nephropathy Rats" @default.
- W2374218675 hasPublicationYear "2010" @default.
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